Evaluating How Well Different Types of Light-sensitive Cells in the Eye Contribute to Its Focusing Ability

Conditions

• L- and M-cone Modulation Only
• L- and S-cone Modulation Only
• M and S-cone Modulation Only
• Monochromatic

Eligibility Criteria

Sex

ALL

Age

N/A - 35 Years

Healthy Volunteers

Accepted

Interventions

• Color — OTHER
  Each intervention involves showing a participant a stimulus with a particular color on a screen display, and asking the participant to focus their eyes on the stimulus. The 4 colors are: 1) grayscale (L, M, and S-cone modulation), 2) L and S cone modulation only, 3) L and M cone modulation only, and 4) M and S cone modulation only.

Study Details

In this experiment, subjects will view shapes on a screen with varying colors and be asked to focus their eyes on the shapes. The shapes will look as though they are jumping to random distances away from the eye. As the subjects focus their eyes on the shapes, the investigators will measure the focus of their eyes using a device called a wavefront sensor. This device uses infrared light to measure the optical properties of the eye in real time. Our goal is to find out how well the eye focuses on different colors. Our broad goal is to better understand how the eye focuses because that process is a major part of having clear and good vision.

Key Dates

First listed

Jul 9, 2026

Start date

Jul 2, 2026

Status verified

Jul 2026

Primary completion

Dec 15, 2026

Completion

Dec 15, 2026

Study Design

Enrollment

20 participants (estimated)

Allocation

NA

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Arms

• Experimental: Color variation in visual stimulus
  Each participant undergoes all experimental conditions, in a within-subjects design. Each intervention corresponds to a different stimulus color. The 4 colors are: 1) grayscale (L, M, and S-cone modulation), 2) L and S cone modulation only, 3) L and M cone modulation only, and 4) M and S cone modulation only.

Primary Outcome Measure

Accuracy of ocular accommodation [ Time Frame: Each measurement takes 3 seconds. In the experiment, there will be two sessions, each lasting approximately 1 hour, on separate days. In each session, a total of 420 measurements will be taken. ]

Central Contacts

• Benjamin M Chin, Doctorate
  8454534320
  [email protected]

Locations (1)

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