Digital and Plasma Biomarkers in Delirium

Part of paid clinical trials in La Jolla, California.

Sponsor
Scripps Health
Study ID
NCT07694206
Status
Recruiting
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Conditions

  • Critical Illness
  • Delirium in the Intensive Care Unit
  • Sleep Quality

Eligibility Criteria

Sex
ALL
Age
65 Years - N/A
Healthy Volunteers
Not accepted

Study Details

The goal of this observational study is to learn if there are potential digital and plasma-based biomarkers that could help detect, predict, and prognosticate delirium in older adult patients who are admitted to the intensive care unit (ICU). The main question DELTA aims to answer is: Can digital biometrics predict and detect delirium in older adult ICU patients? Do biomarkers of neurodegeneration fluctuate in ICU patients in such a way that delrium could potentially be predicted? Participants admitted o the ICU will wear a digital device to collect biometric data and will have serial plasma samples collected during ICU admission and patients will be also assessed for delirium daily by study staff.

Key Dates

First listed
Jul 9, 2026
Start date
May 28, 2026
Status verified
Jul 2026
Primary completion
Oct 30, 2027
Completion
Dec 31, 2027

Study Design

Enrollment
100 participants (estimated)

Arms

  • Arm: DELTA Cohort
    This is the main cohort in which all participants will be enrolled in. These individuals are older adults admitted to the intensive care unit (ICU) with an expected stay of at least 48 hours. Broadly, individuals cannot have advanced dementia at baseline, have liver cirrhosis or be on any kind of renal replacement therapy.

Primary Outcome Measure

Delirium [ Time Frame: Between enrollment and ICU discharge, up to a maximum of 10 days. ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
Scripps Green HospitalLa JollaCalifornia92037
Stuti Jaiswal, MD, PhD
[email protected]
858-554-9100
Scripps Memorial La Jolla HospitalSan DiegoCalifornia92117
Stuti J Jaiswal, MD, PhD
[email protected]
858-554-9100
[email protected]
Stuti J Jaiswal, MD, PhD (PRINCIPAL_INVESTIGATOR)

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