Superior Parietal iTBS for PD-MCI

Conditions

• Mild Cognitive Impairment
• Parkinson Disease

Eligibility Criteria

Sex

ALL

Age

50 Years - 85 Years

Healthy Volunteers

Not accepted

Interventions

• Accelerated intermittent theta-burst stimulation (iTBS) rTMS to right superior parietal lobule (rSPL) — DEVICE
  Participants in this single-arm study will receive a accelerated course of intermittent theta burst stimulation (iTBS) over superior parietal lobule, which is identified with MNI coordinates from past studies. The stimulation will be delivered using a MagVenture MagPro TMS System with a butterfly, active cooling coil at 120% of resting motor threshold. Each participant will complete 3 consecutive treatment days, undergoing10 rTMS sessions per day (600 pulses/session), totaling 18,000 pulses across the study. Safety, tolerability, adherence, and feasibility data will be collected for the intervention.

Study Details

The goal of this study is to determine the whether a short-term, high-dose form of non-invasive brain stimulation (intermittent theta burst stimulation; iTBS) is a promising and safe treatment for mild cognitive impairment in Parkinson's disease (PD-MCI).

Key Dates

First listed

Jul 14, 2026

Start date

Aug 1, 2026

Status verified

Jul 2026

Primary completion

Feb 1, 2028

Completion

Apr 30, 2028

Study Design

Enrollment

30 participants (estimated)

Allocation

NA

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Arms

• Experimental: Accelerated iTBS
  Participants will undergo accelerated intermittent theta burst stimulation (iTBS) targeting the right superior parietal lobule (rSPL) using a MagVenture MagPro system with a cooled butterfly coil, with Brainsight neuronavigation identifying the stimulation site. Resting motor threshold (rMT) will be determined on the first stimulation visit using Parameter Estimation by Sequential Testing (PEST). Stimulation for the intervention will be delivered at 120% rMT. Stimulation sessions will occur over three consecutive days. Each day will include 10 sessions separated by 10-15 min. Each session delivers 600 pulses (50 Hz triplets; 2 s on/8 s off; \~190 seconds), totaling 6,000 pulses/day and 18,000 pulses overall. Coil position/angle and scalp-to-cortex distance are tracked; tolerability/acceptability (headache, pain, scalp irritation, facial twitching, fatigue, fear/anxiety) will be assessed before and after sessions.

Primary Outcome Measure

Serious Adverse Events [ Time Frame: Week 4, 5 minutes before and 5 minutes after stimulation sessions on Days 1-3 ]

Locations (1)

Find similar trials in Charleston, SC

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