Paid Clinical Trials in Charleston, SC
As of July 2026, 683 paid clinical trials are recruiting in Charleston, South Carolina. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Charleston offers studies at sites including Medical University of South Carolina for conditions such as Stroke, Depression, Heart Failure, Acute Myeloid Leukemia. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in Charleston
Trials by drug in Charleston
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Newly added in Charleston
Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.
Superiority Trial of Aphasia-focused Rehabilitation With tDCS Stimulation
A Phase 3 Efficacy and Safety Study of HBS-301 in Participants With Narcolepsy
A Master Protocol to Investigate Efficacy and Safety of Elecoglipron in Participants With Obesity or Overweight With or Without T2DM
Outcomes Associated With Tirbanibulin for Large Field Application on the Face in the U.S (CLEAR)
A Phase IIb Study to Evaluate AZD8965 in Participants With IPF.
608 clinical trials
A Study to Evaluate Efficacy, Safety, and Immunogenicity With ABP 938 8 mg Versus EYLEA® HD (Aflibercept) in Participants With Neovascular Age-related Macular Degeneration
A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity
A Phase 2/3 Study of Brepocitinib in Adults With Lichen Planopilaris
A Study to Evaluate Chemotherapy With or Without INCB161734 in Previously Untreated, KRAS G12D-Mutated Metastatic Pancreatic Ductal Adenocarcinoma
A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-002)
LY4268989 in Adults With Moderately to Severely Active Ulcerative Colitis
Study to Evaluate the Safety and Efficacy of Larsucosterol in Participants With Alcohol-associated Hepatitis (AH)
A 26-Wk Study to Assess Safety & Efficacy of Tenapanor for T/t of Chronic Idiopathic Constipation in Adults
A Study to Test Whether BI 3802876 is Tolerated in People With Compensated Liver Cirrhosis Due to Metabolic Dysfunction- Associated Steatohepatitis (MASH)
Parasternal Extravascular ICD System Pivotal Clinical Investigation (ALARION EV) Study
A Study of Buntanetap in Participants With PD
A Study Evaluating BFB759 in Moderate to Severe Hidradenitis Suppurativa
A Study to Investigate Safety and Efficacy of Tapinarof Cream, 1% in Participants Ages 3 Months to < 24 Months With Atopic Dermatitis
A Study to Evaluate the Efficacy, Safety, and Tolerability of VIM0423 in Individuals With Isolated Dystonia
A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)
A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Parts B and C) Ovarian Cancer
Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's Disease Studies
Assessing the Impact of Muvalaplin on Major Cardiovascular Events in Adults With Elevated Lipoprotein(a)
OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events
A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-038)
A Study of Pasritamig Versus Placebo in Late Line Metastatic Castration-resistant Prostate Cancer (mCRPC)
LIVERAGE™: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Moderate or Advanced Liver Fibrosis
Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63)
A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence
A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)
A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)
Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer
Phase 2/3 Adaptive Study of VX-147 in Adult and Pediatric Participants With APOL1-Mediated Proteinuric Kidney Disease
A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)
A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer
Study to Assess the Injection Burden, Adverse Events, Change in Disease Activity, and Long-Term Preservation of Visual Acuity of Surabgene Lomparvovec in Adult Participants With Neovascular Age-Related Macular Degeneration (nAMD)
A Study to Learn About the Study Medicine Ibuzatrelvir in Adults With COVID-19 Who Are Severely Immunocompromised
Evaluation of Efficacy and Safety of Suzetrigine for Pain Associated With Diabetic Peripheral Neuropathy
A Study to Evaluate Efficacy of Remibrutinib Compared to Dupilumab at Early Timepoints in Adults With Chronic Spontaneous Urticaria Inadequately Controlled by Second Generation H1-antihistamines
A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004)
A Study to Evaluate the Safety and Efficacy of Ruxolitinib Cream in Pediatric Participants With Nonsegmental Vitiligo
A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular Events
A Study to Evaluate Efficacy and Safety of Giredestrant Compared With Fulvestrant (Plus a CDK4/6 Inhibitor), in Participants With ER-Positive, HER2-Negative Advanced Breast Cancer Resistant to Adjuvant Endocrine Therapy (pionERA Breast Cancer)
A Study to Assess Adverse Events and How Intravenously (IV) Infused Telisotuzumab Vedotin (ABBV-399) Moves Through the Body as a Monotherapy in Adult Participants With Previously Treated Non-Squamous Non-Small Cell Lung Cancer (NSCLC)
Study Assessing Activity of Intravenous (IV) Etentamig Monotherapy Versus Standard Available Therapies in Adult Participants With Relapsed or Refractory Multiple Myeloma
Top Research Study Locations in Charleston
Researchers run research studies in Charleston, SC at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Medical University of South Carolina | Stroke, Depression, Parkinson Disease | 382 |
| Medical University of South Carolina (MUSC) | ARDS, ARDS (Acute Respiratory Distress Syndrome), Acute Respiratory Distress Syndrome | 27 |
| Ralph H. Johnson VA Medical Center, Charleston, SC | Stroke, Depression, PTSD | 22 |
| Ralph H Johnson VA Medical Center | Stage IV Lung Cancer AJCC v8, Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum | 11 |
| MUSC | Tricuspid Valve Disease, Cardiovascular Diseases, Focal Epilepsy | 7 |
| Medical University of South Carolina Hollings Cancer Center | Brain Metastases, Cancer (With CNS Involvement), Locally Advanced Pancreatic Adenocarcinoma | 7 |
| Hollings Cancer Center | Acute Myeloid Leukemia, Breast Cancer, Chronic Myelomonocytic Leukemia | 6 |
| MUSC Hollings Cancer Center | Advanced Renal Cell Carcinoma (RCC), Advanced Solid Tumor, Cachexia | 6 |
| Ralph H. Johnson VA Health Care System | Adjustment Disorders, Agitation, Alzheimer Disease | 6 |
| GSK Investigational Site | Asthma, Chickenpox, Hypereosinophilic Syndrome | 4 |
| Bon Secours Saint Francis Hospital | Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8, HER2-Negative Breast Carcinoma | 4 |
| Hollings Cancer Center at Medical University of South Carolina | B-cell Non Hodgkin Lymphoma, Chronic Lymphocytic Leukemia, Locally Advanced Pancreatic Adenocarcinoma | 4 |
| Medical University of South Carolina Children's Hospital | Focal Segmental Glomerulosclerosis, Adrenal Insufficiency, Arrythmia | 4 |
| Medical University of South Carolina University Hospital | Intracerebral Hemorrhage, Ischemic Stroke, Atrial Fibrillation | 4 |
| Lowcountry Lung and Critical Care, PA | Idiopathic Hypersomnia, Idiopathic Pulmonary Fibrosis (IPF), OSA | 3 |
| Medical University South Carolina | Knee Arthroplasty, Total, Lower Respiratory Tract Infection, Myasthenia Gravis | 3 |
| Roper Hospital | Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8, HER2-Negative Breast Carcinoma | 3 |
| University of South Carolina | Alpha1-Antitrypsin Deficiency, Growth Hormone Deficiency, Lupus Nephritis | 3 |
| Charleston Neuroscience Institute | NAION( Non-arteritic Anterior Ischemic Optic Neuropathy), Neovascular Age-related Macular Degeneration, Open Angle Glaucoma (OAG) | 3 |
| 30 Bee Street | Depression, Post Stroke Pain | 2 |
| 89bio Clinical Study Site | Metabolic Dysfunction-Associated Steatohepatitis (MASH) / Nonalcoholic Steatohepatitis (NASH) With Compensated Cirrhosis, Metabolic Dysfunction-Associated Steatotic Liver Disease (MASH) / Nonalcoholic Steatohepatitis (NASH) With Fibrosis | 2 |
| Akero Clinical Study Site | MASH - Metabolic Dysfunction-Associated Steatohepatitis, MASH With Fibrosis, NASH - Nonalcoholic Steatohepatitis | 2 |
| Charleston Neuroscience Institute, LLC (Charleston) | Macular Edema Secondary to Inflammation | 2 |
| Charleston Oncology - Roper | Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8, HER2-Negative Breast Carcinoma | 2 |
| Charleston Oncology - Saint Francis | Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8, HER2-Negative Breast Carcinoma | 2 |
Active & Upcoming Studies in Charleston (2026)
Recruiting trials in Charleston grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (166 active studies)
- Study of Autologous, Metabolically Optimized, CD137+ Tumor-Infiltrating Lymphocytes Followed by Consolidative Oral Cyclophosphamide, Bevacizumab, and Pembrolizumab · Phase 2 · Medical University of South Carolina
- Cemiplimab for Clinical Stage I, 2-3.9cm, Non-Small Cell Lung Cancer · Phase 2 · Medical University of South Carolina
Neurology & pain (61 active studies)
- Prescriptive Infusion Algorithm (PIA) · Phase 2 · AskBio Inc
- Superior Parietal iTBS for PD-MCI · Medical University of South Carolina
Mental health & behavior (60 active studies)
- PTSD and Alcohol Couples Treatment for Veterans · EARLY_Phase 1 · VA Office of Research and Development
- Treatment of Depression Post-SCI · Medical University of South Carolina
Cardiovascular (52 active studies)
Diabetes & metabolic (15 active studies)
- A Research Study Investigating How Well the Medicine Zenagamtide Helps People With Excess Body Weight Lose Weight Compared to Semaglutide · Phase 3 · Novo Nordisk A/S
- Development of a MHBC Intervention for Weight Loss and Smoking Cessation for Pre-Bariatric Surgery Patients · Phase 1 · Medical University of South Carolina
Pediatric (14 active studies)
- The CATSINDO Trial - Clinical and Translational Study in Newly Diagnosed Osteosarcoma · Phase 2 · Wake Forest University Health Sciences
- A Pragmatic Clinical Trial of the WE BEAT Well-Being Education Program in Adolescent Congenital Heart Disease: WE BEAT CHD Study · Carelon Research
Eye & vision (11 active studies)
Vaccines (4 active studies)
- A Study to Learn About the Study Medicine Ibuzatrelvir in Adults With COVID-19 Who Are Severely Immunocompromised · Phase 3 · Pfizer
- A Surveillance Study of Susceptibility to Baloxavir Marboxil in Pediatric Participants With Influenza and Transmission of Influenza to Household Contacts · Phase 3 · Hoffmann-La Roche
HIV / STI (3 active studies)
- Engaging Pharmacists to Advance Tobacco Treatment Service Delivery · Medical University of South Carolina
- Development and Evaluation of a Virtual Reality Tool for At-Risk Trauma-Exposed Young People · Medical University of South Carolina
Common conditions studied in Charleston
- Stroke (15 active studies)
- Depression (13 active studies)
- Heart Failure (13 active studies)
- Acute Myeloid Leukemia (8 active studies)
- Cancer (8 active studies)
- Cardiovascular Diseases (8 active studies)
Leading research sponsors in Charleston
- Medical University of South Carolina
- National Cancer Institute (NCI)
- VA Office of Research and Development
- AstraZeneca
- NRG Oncology
Frequently asked questions
How many paid clinical trials are currently recruiting in Charleston?
There are approximately 683 recruiting clinical trials in Charleston, South Carolina listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Charleston pay participants?
Most recruiting trials in Charleston compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Charleston?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Charleston?
The most common conditions under active study in Charleston include Stroke (15), Depression (13), Heart Failure (13), Acute Myeloid Leukemia (8), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Charleston?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Charleston on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Charleston?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Charleston?
Recruiting research sites in Charleston include Medical University of South Carolina, Medical University of South Carolina (MUSC), Ralph H. Johnson VA Medical Center, Charleston, SC, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Charleston right now?
The largest active categories in Charleston are Cancer & tumors (166), Neurology & pain (61), Mental health & behavior (60). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.