Flow Cytometric Immune Monitoring of B. Afzelii-Specific T Lymphocytes

Sponsor
University Hospital, Strasbourg, France
Study ID
NCT07703787
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Study Details

Lyme borreliosis diagnosis currently relies on clinical assessment and detection of Borrelia-specific antibodies. However, serology does not allow reliable assessment of active infection. Evaluation of the cellular immune response through Borrelia-specific T lymphocyte monitoring may provide complementary diagnostic and prognostic information. This study aims to assess Borrelia afzelii-specific T-cell responses using multiparameter flow cytometry after stimulation with standardized peptide pools. This approach enables the characterization of CD4+ and CD8+ T cells, including polyfunctional immune responses. The diagnostic and prognostic value of this immunomonitoring strategy will be evaluated in patients with acrodermatitis chronica atrophicans, a late manifestation of Lyme borreliosis associated with B. afzelii.

Key Dates

First listed
Jul 14, 2026
Start date
Sep 30, 2026
Status verified
Jul 2026
Primary completion
Mar 31, 2029
Completion
Mar 31, 2029

Study Design

Enrollment
20 participants (estimated)

Arms

  • Arm: Lyme borreliosis / Acrodermatitis chronica atrophicans (ACA) group
  • Arm: Control group

Primary Outcome Measure

Characterization of Borrelia afzelii-specific T-cell immune responses by multiparameter flow cytometry [ Time Frame: At study inclusion (baseline visit) ]

Central Contacts

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