Sex-Divergent Effects of Magnesium L-Threonate Supplementation on Sleep Quality, Cognitive Performance, and Neuromuscular Function in Healthy Adults

Conditions

• Healthy Adults; Cognitive Performance; Sleep Quality; Neuromuscular Function

Eligibility Criteria

Sex

ALL

Age

18 Years - 45 Years

Healthy Volunteers

Accepted

Interventions

• Magnesium L-threonate — DIETARY_SUPPLEMENT
  Magnesium L-threonate
• Placebo — DIETARY_SUPPLEMENT
  Rice powder

Study Details

This study examined the effects of six weeks of magnesium L-threonate (MgT) supplementation on sleep quality, cognitive performance under experimentally induced mental fatigue, neuromuscular function, and psychophysiological outcomes in healthy adults. Biological sex and weight status were examined as pre-specified moderating variables.

Key Dates

First listed

Jul 15, 2026

Start date

Dec 1, 2025

Status verified

Jul 2026

Primary completion

Mar 19, 2026

Completion

Mar 19, 2026

Study Design

Enrollment

81 participants (actual)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Arms

• Experimental: Magnesium L-Threonate (MgT)
  Participants consumed 2 g·day-¹ of magnesium L-threonate (Magtein®; AIDP Inc., City of Industry, CA, USA) once daily for six weeks.
• Placebo Comparator: Placebo
  Participants consumed visually identical capsules containing rice powder (1.4 g·day-¹) once daily for six weeks. Capsules were matched to the intervention in appearance and dosing schedule.

Primary Outcome Measure

Pittsburgh Sleep Quality Index (PSQI) [ Time Frame: Baseline (Week 0) and post-intervention (Week 6) ]

Locations (1)

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