Can Two Dietary Interventions Maintain Weight Loss for 12 Months After GLP-1 Therapy in Adults With Overweight/Obesity?

Sponsor
Knut Mai
Study ID
NCT07711548
Status
Not Yet Recruiting

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Conditions

  • Obesity & Overweight
  • Weight Loss Maintenance

Eligibility Criteria

Sex
ALL
Age
18 Years - 70 Years
Healthy Volunteers
Not accepted

Interventions

  • NutriAct plus — BEHAVIORAL
    Dietary pattern, vegetarian version of the NutriAct pattern
  • Rescue VLCD — BEHAVIORAL
    Very low calorie diet as full meal replacement over 28 days in case of weight regain

Study Details

So far, treatment with semaglutide (Wegovy) for therapy of obesity demonstrates substantial effects. However, most patients do not desire life-long pharmaceutical therapy or discontinue this treatment regime. This is accompanied by rapid weight regain. Moreover, numerous patients are open to an intermittent therapy. This trial aims to investigate whether two diet interventions can keep weight stable after weight loss with semaglutide in people with obesity or overweight.

Key Dates

First listed
Jul 17, 2026
Start date
Mar 31, 2027
Status verified
Jul 2026
Primary completion
Feb 28, 2030
Completion
Apr 30, 2030

Study Design

Enrollment
292 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER

Arms

  • Other: NutriAct plus
    Adults with obesity who have lost \>= 7% of their body weight with semaglutide therapy over 3-5 months and who will follow NutriAct plus for 12 months
  • Other: Rescue VLCD
    Adults with obesity who have lost \>= 7% of their body weight with semaglutide therapy over 3-5 months and who will receive rescue VLCD in case of weight regain for 12 months

Primary Outcome Measure

weight in kg [ Time Frame: body weight in kg after weight loss (3 to 5 months) and dietary intervention (12 months) ]

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