Understanding the Paradoxical Rise in Blood Glucose in the Context of a Low-carbohydrate Diet

Conditions

• Elevated Blood Glucose
• Low-carbohydrate Diet

Eligibility Criteria

Sex

ALL

Age

18 Years - 65 Years

Healthy Volunteers

Not accepted

Interventions

• Carbohydrate Drink — DIETARY_SUPPLEMENT
  300 kcal of dextrose mixed in water.
• Fat Drink — DIETARY_SUPPLEMENT
  300 kcal of olive oil mixed in water.
• Protein Drink — DIETARY_SUPPLEMENT
  300 kcal of whey protein in water.

Study Details

The purpose of this project was to elucidate the phenomenon of elevated blood glucose in the context of dietary carbohydrate restriction. Accordingly, we sought to quantify glucagon, and related hormones, between individuals that are adhering to a low-carbohydrate diet that manifests with normal vs. elevated glucose. Moreover, we sought to test the dynamic effect of macronutrients on these same outcomes. Each participant completed 3 testing periods that included the consumption of a glucose drink, protein drink, or fat (olive oil) drink in a random order and separated by at least 2 days. Each drink was matched for volume and total calories and bloodwork was taken every 30 minutes to assess the outcomes of interest.

Key Dates

First listed

Jul 20, 2026

Start date

May 15, 2021

Status verified

Jul 2026

Primary completion

Jun 30, 2022

Completion

Dec 17, 2022

Study Design

Enrollment

24 participants (actual)

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

SUPPORTIVE_CARE

Arms

• Experimental: Carbohydrate Drink
  carbohydrate
• Active Comparator: Fat Drink
  Fat
• Active Comparator: Protein Drink
  Protein

Primary Outcome Measure

Interstitial glucose (continuous glucose monitoring) [ Time Frame: 2 hours after consuming the beverage ]

Locations (1)

Find similar trials in Provo, UT