Dorsal Root Electrical Stimulation in Children With Cerebral Palsy

Part of paid clinical trials in Pittsburgh, Pennsylvania.

Sponsor
Martin Piazza
Study ID
NCT07715006
Status
Recruiting
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Conditions

  • Cerebral Palsy
  • Cerebral Palsy (CP)
  • Spasticity
  • Spasticity Due to Cerebral Palsy

Eligibility Criteria

Sex
ALL
Age
3 Years - 14 Years
Healthy Volunteers
Not accepted

Interventions

  • Constant Current Stimulator — DEVICE
    The DS8R is an external isolated stimulator system used in human research (DS8R), delivers controlled electrical pulses with adjustable stimulation parameters.
  • Cadwell Guardian System — DEVICE
    The Cadwell Guardian System is a clinical intraoperative system used to deliver stimulation in the dorsal root during SDR.

Study Details

The goal of this clinical trial is to evaluate whether dorsal root electrical stimulation could reduce spasticity in children with cerebral palsy (CP).

Key Dates

First listed
Jul 20, 2026
Start date
Jul 16, 2026
Status verified
Jul 2026
Primary completion
Nov 1, 2029
Completion
Dec 1, 2029

Study Design

Enrollment
15 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Cerebral Palsy Group
    The investigators will use the DS8R to directly deliver electrical stimulation with hook electrodes to the dorsal roots while testing the spasticity of individual dorsal roots.

Primary Outcome Measure

Peak-to-peak amplitude of the dorsal root reflex [ Time Frame: In session during the surgery (1 session) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
UPMC Children's Hospital of PittsburghPittsburghPennsylvania15224
Bailey G McDonald, BS
[email protected]
412-692-9966
Martin G Piazza, MD
[email protected]
Martin G Piazza, MD (PRINCIPAL_INVESTIGATOR)
Genis Prat-Ortega, PhD (SUB_INVESTIGATOR)
Taylor Abel, MD (SUB_INVESTIGATOR)
Jeffrey Balzer, PhD (SUB_INVESTIGATOR)

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By research site
UPMC Children's Hospital of Pittsburgh· Pittsburgh, PA

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