Trifecta Research Study

Part of paid clinical trials in Northridge, California.

Sponsor
Axial Therapeutic Research
Study ID
NCT07717866
Status
Active Not Recruiting

Conditions

  • Brain Injury
  • Cognitive Dysfunction
  • Depression - Major Depressive Disorder
  • PTSD - Post Traumatic Stress Disorder
  • Suicidal Ideation

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Magnetic e-Resonance Therapy (MeRT) — DEVICE
    MeRT, an electroencephalography (EEG)-guided Repetitive Transcranial Magnetic Stimulation therapy, is a non-invasive treatment that uses magnetic pulses to modulate neural networks of the brain, guided by an individual's brain patterns. MeRT is a neuromodulatory tool that has shown therapeutic efficacy in relation to decreasing severity of PTSD symptoms. There is preliminary data showing MeRT's therapeutic impact on depression and TBI-related cognitive impairment through promoting cortical excitability, modulating neurotransmission, and restoring neuroplasticity.
  • Ibogaine Hydrochloride with Magnesium Sulfate — DRUG
    Ibogaine hydrochloride was administered orally. Ibogaine is an indole alkaloid that together with its metabolites interacts with mu opioid, kappa opioid, N-methyl-D-aspartate receptor (NMDA), and nicotinic acetylcholine receptors. Ibogaine has shown early signs of effectiveness as a rapid-acting treatment for a number of mental health disorders including PTSD and substance use disorder. Magnesium sulfate was administered intravenously prior to Ibogaine administration and orally each day.
  • 5-methoxy-N,N-dimethyltryptamine — DRUG
    5-MeO-DMT is administered by using a pipe to inhale a vapor that is produced by heating a canister containing a powder form of the substance. 5-MeO-DMT is a 5-HT-1A and 5-HT-2A agonist compound that has shown early signs of effectiveness in treating depression. Inhaled 5-MeO-DMT has a short duration of action, producing an intense, time-limited psychoactive state.
  • Physiological Supplementation — DRUG
    Physiological Supplementation describes a treatment program aimed at restoring healthy endocrine functioning, using supplements such as the following: Synthetic testosterone, Anastrozole, Gonadorelin, Vitamin and amino acid supplementation, Fish oil, Ipamorelin.

Study Details

This observational study evaluates the impact of Ibogaine-Magnesium (IM), 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT), Magnetic e-Resonance Therapy (MeRT), and Physiological Supplementation (PS) on posttraumatic stress disorder (PTSD) and traumatic brain injury-related cognitive symptoms among Special Operations Forces (SOF) combat veterans.

Key Dates

First listed
Jul 21, 2026
Start date
Aug 1, 2022
Status verified
Jul 2026
Primary completion
Feb 1, 2026
Completion
Nov 30, 2026

Study Design

Enrollment
52 participants (actual)

Arms

  • Arm: Intervention Sequence 1
    Individuals in this arm will undergo Physiological Supplementation, then Ibogaine and 5-MeO treatment, and then MeRT therapy.
  • Arm: Intervention Sequence 2
    Individuals in this arm will undergo Physiological Supplementation, then MeRT therapy, and then Ibogaine and 5-MeO-DMT.

Primary Outcome Measure

PTSD Checklist for Diagnostic and Statistical Manual (DSM)-5 (PCL-5) [ Time Frame: Up to 12 months follow up ]

Locations (1)

FacilityCityStateZIPSite coordinators
Axial Therapeutic ResearchNorthridgeCalifornia91325-

Find similar trials in Northridge, CA

By research site
Axial Therapeutic Research· Northridge, CA

Related Studies