Early Postoperative L-arginine and Acute Kidney Injury After Cardiac Surgery

Sponsor
Xijing Hospital
Study ID
NCT07718373
Status
Not Yet Recruiting

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Conditions

  • Acute Kidney Injury

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • L-arginine — DRUG
    Initiation of L-arginine within 3 postoperative days

Study Details

Acute kidney injury (AKI) is common after cardiac surgery, yet effective protective strategies remain limited. L-arginine is the substrate for endogenous nitric oxide (NO) synthesis and may improve renal perfusion and endothelial function. investigators emulated a target trial to evaluate whether early perioperative L-arginine was associated with a lower risk of AKI after cardiac surgery.

Key Dates

First listed
Jul 22, 2026
Start date
Jul 20, 2026
Status verified
Jul 2026
Primary completion
Aug 20, 2026
Completion
Aug 20, 2026

Study Design

Enrollment
5,000 participants (estimated)

Arms

  • Arm: L-arginine
    Initiation of L-arginine within 3 postoperative days
  • Arm: No L-arginine
    No L-arginine therapy within 3 postoperative days

Primary Outcome Measure

Acute kidney injury [ Time Frame: within 7 postoperative days ]

Central Contacts

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