FST Analysis Supporting Timely Therapy and Risk Assessment Via Clinical Decision Support for Kids

Part of paid clinical trials in Cincinnati, Ohio.

Sponsor
Children's Hospital Medical Center, Cincinnati
Study ID
NCT07718464
Status
Recruiting
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Conditions

  • Acute Kidney Injury
  • Pediatric Intensive Care Unit
  • Renal Replacement Therapy

Eligibility Criteria

Sex
ALL
Age
N/A - N/A
Healthy Volunteers
Not accepted

Interventions

  • Furosemide Stress Test Clinical Decision Support Tool — OTHER
    The CDS strategy will be developed with key stakeholders in the Cincinnati Children's PICU, leveraging existing infrastructure and workflows. This CDS intervention will then be implemented as part of routine care in the PICU.

Study Details

The goal of this study is to learn whether adding a clinical decision support tool to the electronic medical record helps clinicians use the furosemide stress test in critically ill children at high risk for severe acute kidney injury (AKI). The main question it aims to answer is: Does implementing the decision support tool reduce fluid overload and help predict which children will receive dialysis? Researchers will identify children admitted to the pediatric intensive care unit who are at high risk for AKI using risk stratification and biomarker testing, then compare outcomes in the two years after the tool is introduced with the two years before.

Key Dates

First listed
Jul 22, 2026
Start date
May 27, 2026
Status verified
Jul 2026
Primary completion
May 31, 2028
Completion
Jun 30, 2028

Study Design

Enrollment
120 participants (estimated)

Arms

  • Arm: Post-Implementation Cohort
    All patients with RAI greater than or equal to 8 (RAI+) and NGAL greater than or equal to 150 ng/mL (NGAL+) in the two years after the clinical decision support tool is implemented. These patients will be compared to the cohort of patients with RAI greater than or equal to 8 and NGAL greater than or equal to 150 ng/mL in the two years before the clinical decision support (CDS) tool is implemented.

Primary Outcome Measure

Change in Day 7 Fluid Accumulation [ Time Frame: 2 years ]

Locations (1)

FacilityCityStateZIPSite coordinators
Cincinnati Children's Hospital Medical CenterCincinnatiOhio45229
Natalja L Stanski, MD, MS
[email protected]
513-636-4334
Natalja L Stanski, MD, MS (PRINCIPAL_INVESTIGATOR)
Imogen Clover-Brown, MD (SUB_INVESTIGATOR)

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