UW ISeqU: Clinical Impact of Whole-genome Sequencing in Adults

Part of paid clinical trials in Seattle, Washington.

Sponsor
University of Washington
Study ID
NCT07718971
Status
Enrolling By Invitation

Conditions

  • Critical Illness
  • Hereditary Diseases

Eligibility Criteria

Sex
ALL
Age
18 Years - 50 Years
Healthy Volunteers
Not accepted

Interventions

  • Genome sequencing — GENETIC
    Clinical whole-genome sequencing of blood or buccal DNA, with optional family comparator analysis and return of clinical results

Study Details

The goal of this study is to learn how clinical whole genome sequencing can help identify diagnoses and guide medical care in adults. The study is based on the hypothesis that genome sequencing will identify a genetic explanation in some adults whose condition has not previously been diagnosed and that some results will change medical care. The main questions it aims to answer are: * How often does genome sequencing identify a genetic diagnosis that explains or contributes to a participant's symptoms? * How do genetic results affect medical care and decision-making? * Is genome sequencing feasible and acceptable to adult patients and families? * Are there differences in access to genetic testing or diagnosis across different groups of patients? Participants will: * Provide a blood sample (often collected during routine care) or cheek swab for genetic testing * Allow researchers to review their medical records * Receive genetic results that will also be shared with their medical team * May be asked to complete a brief survey or interview about their experience Researchers will follow participants over time to understand how genetic testing impacts diagnosis and care.

Key Dates

First listed
Jul 22, 2026
Start date
Jul 1, 2026
Status verified
Jul 2026
Primary completion
Jul 1, 2029
Completion
Jul 1, 2032

Study Design

Enrollment
1,000 participants (estimated)

Arms

  • Arm: Adults Undergoing Clinical Genome Sequencing
    Adults with unexplained medical conditions or clinical presentations who undergo clinical genome sequencing and longitudinal follow-up

Primary Outcome Measure

Diagnostic Yield of Clinical Genome Sequencing [ Time Frame: Through study completion, an average of 3 years ]

Locations (1)

FacilityCityStateZIPSite coordinators
University of Washington Medical CenterSeattleWashington98195-

Find similar trials in Seattle, WA

By research site
University of Washington Medical Center· Seattle, WA

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