Acetaminophen vs Placebo for Postoperative Analgesia After Abdominal Surgery

Sponsor
Konya City Hospital
Study ID
NCT07720791
Phase
PHASE4
Status
Not Yet Recruiting

Notify me when recruiting opens

Save your spot on the interest list for this study. We'll keep your details with this study so our team can follow up when recruiting opens.

Not yet recruiting

Add your contact details and location so we can keep your interest tied to this study.

Conditions

  • Pain, Postoperative

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Acetaminophen — DRUG
    Intervention 1: Acetaminophen (Type: Drug) Oral acetaminophen 1000 mg tablet, administered 30 minutes before surgery and every 6 hours postoperatively until 48 hours after surgery. Other Name(s): Paracetamol Intervention 2: Placebo (Type: Other / Drug) Oral placebo tablet, visually identical to the acetaminophen tablet, administered on the same schedule (30 minutes before surgery and every 6 hours postoperatively until 48 hours after surgery).

Study Details

This study investigates whether oral acetaminophen, when added to standard pain management, reduces opioid use and pain after major abdominal surgery, compared to a placebo (inactive pill). Patients undergoing planned abdominal surgery under general anesthesia will be randomly assigned to receive either acetaminophen or a placebo tablet before surgery and every 6 hours afterward for 48 hours, in addition to their usual pain medication. Researchers will measure how much opioid pain medication patients need, how much pain they report, and how satisfied they are with their pain control during the first two days after surgery. The goal is to determine whether oral acetaminophen provides a genuine benefit beyond placebo in reducing opioid use while maintaining adequate pain control.

Key Dates

First listed
Jul 22, 2026
Start date
Jul 15, 2026
Status verified
Jul 2026
Primary completion
Jul 15, 2027
Completion
Aug 1, 2027

Study Design

Enrollment
1,504 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: Acetaminophen
    Arm 1: Acetaminophen (Arm Type: Experimental) Participants will receive oral acetaminophen 1000 mg, administered 30 minutes before surgery and every 6 hours postoperatively for 48 hours.
  • Placebo Comparator: Placebo
    Participants will receive a matching placebo tablet, administered 30 minutes before surgery and every 6 hours postoperatively for 48 hours.

Primary Outcome Measure

Total Postoperative Opioid Consumption [ Time Frame: 48 hours after surgery ]

Central Contacts

Related Studies