Memory Enhancement in Aging With Closed-Loop tACS

Sponsor
Boston University Charles River Campus
Study ID
NCT07722598
Status
Not Yet Recruiting

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Conditions

  • Aging
  • Memory
  • Noninvasive Brain Stimulation

Eligibility Criteria

Sex
ALL
Age
65 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Peak Frequency — DEVICE
    Device: High definition transcranial electrical current stimulation Low-intensity, noninvasive application of electrical current to the human scalp tailored to individual peak frequency with the goal of modulating levels of neuronal excitability.
  • Phase Lag — DEVICE
    Device: High definition transcranial electrical current stimulation Low-intensity, noninvasive application of electrical current to the human scalp tailored to individual phase lag with the goal of modulating levels of neuronal excitability.
  • Peak Frequency + Phase Lag — DEVICE
    Device: High definition transcranial electrical current stimulation Low-intensity, noninvasive application of electrical current to the human scalp tailored to individual peak frequency and phase lag with the goal of modulating levels of neuronal excitability.
  • Non-Adpative — DEVICE
    Device: High definition transcranial electrical current stimulation Low-intensity, noninvasive application of electrical current to the human scalp not tailored to individual peak frequency or phase lag with the goal of modulating levels of neuronal excitability.

Study Details

This project optimizes high-resolution tACS to improve memory in healthy older adults, advancing drug-free approaches for ADRD. We test stimulation schedules and develop an adaptive, brain-guided tACS system to strengthen memory-supporting networks.

Key Dates

First listed
Jul 23, 2026
Start date
May 1, 2028
Status verified
Jul 2026
Primary completion
Jan 31, 2031
Completion
Jan 31, 2031

Study Design

Enrollment
160 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Peak Frequency
  • Experimental: Phase Lag
  • Experimental: Peak Frequency + Phase Lag
  • Experimental: Non-Adaptive

Primary Outcome Measure

EEG phase locking value (PLV) during working memory retention [ Time Frame: Baseline, Day 2 ]

Central Contacts

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