Split Face Study of the Duration of Local Anesthetics - Fifth Arm

Conditions

• This Study Will Focus on In-office Dermatological Procedures

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Accepted

Interventions

• Lidocaine HCl/Epinephrine — DRUG
  Injection of lidocaine solution for local anesthesia. Participants will receive lidocaine via either intradermal or subcutaneous administration at a volume of 0.5 mL or 1.0 mL.

Study Details

This study will compare how long local anesthesia lasts when it is injected into different layers of the skin on the forearm. The investigators hypothesize that the numbing effect will last for different amounts of time depending on whether the medication is injected just under the skin or into the skin itself.

Key Dates

First listed

Jul 24, 2026

Start date

Aug 1, 2026

Status verified

Jul 2026

Primary completion

Jun 30, 2027

Completion

Jun 30, 2027

Study Design

Enrollment

50 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• Experimental: Intradermal administration of 0.5mL of lidocaine
• Experimental: Subcutaneous administration of 0.5mL of lidocaine
• Experimental: Intradermal administration of 1.0mL of lidocaine
• Experimental: Subcutaneous administration of 1.0mL of lidocaine

Primary Outcome Measure

Duration of anesthesia [ Time Frame: From injection until return of sharp sensation, up to 6 hours ]

Central Contacts

• Kira Minkis, MD, PhD
  6469627948
  [email protected]
• Fengrui Zhan, BS
  6073797248
  [email protected]

Locations (1)

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