Effect of FPP on Cutaneous Barrier Integrity

Conditions

• Skin Hydration in Healthy Volunteers

Eligibility Criteria

Sex

ALL

Age

50 Years - 75 Years

Healthy Volunteers

Accepted

Interventions

• Fermented Papaya Preparation (FPP) — DIETARY_SUPPLEMENT
  Immun'Age Fermented Papaya Preparation

Study Details

This pilot study will test how Fermented Papaya Preparation (FPP) impacts overall TEWL of areas that commonly display diminished barrier function, such as the skin from face, arms, and hands. Areas of diminished barrier function are defined as those not visible to the eye but identified as areas of high transepidermal water loss (TEWL) as measured by a non-invasive pen-like device. A TEWL value of 20 or higher at a location would be considered high TEWL. Participants will attend 5 visits over 20 weeks, with 12-weeks of FPP treatment, and 8-weeks of follow-up.

Key Dates

First listed

Jul 24, 2026

Start date

Jul 31, 2026

Status verified

Jul 2026

Primary completion

Apr 30, 2028

Completion

Jul 31, 2028

Study Design

Enrollment

30 participants (estimated)

Allocation

NA

Intervention model

SINGLE_GROUP

Primary purpose

OTHER

Arms

• Experimental: Fermented Papaya Preparation
  Fermented Papaya Preparation Supplement

Primary Outcome Measure

Transepidermal Water Loss (TEWL) [ Time Frame: From enrollment to the end of FPP at 12 weeks. ]

Central Contacts

• Savita Khanna, PhD
  412-624-5500
  [email protected]
• Scot King, DPT
  [email protected]

Locations (1)

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