STRIDE: Strength of The Calf Muscles and Their Role In Declining Effectiveness of Movement With Aging

Sponsor
University of Leicester
Study ID
NCT07726498
Status
Not Yet Recruiting

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Conditions

  • Aging
  • Frailty
  • Muscle Weakness or Atrophy
  • Sarcopenia

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • No intervention (observational study) — OTHER
    No intervention (observational study)

Study Details

The calf muscles (plantarflexors) are the most important muscles for walking, running and daily activities. Weakness of these muscles through aging and disease significantly impact a person's ability to walk and complete daily activities. By assessing calf strength, it is possible to identify people at risk of falls, and a condition called sarcopenia (which means loss of muscle mass, strength and function). Unfortunately, most of the studies that have examined this have used specialist equipment unavailable to hospital staff. Our study aims to use commercially available equipment to explore the relationship between plantarflexor muscle strength and physical performance in adults living with or without sarcopenia, including those at risk of it. The study will determine if stronger/weaker calf muscles associated with sarcopenia influence the ability to walk and do things more easily. We will complete strength tests of the calf, thigh and hand, assess walking using a special camera system, use an ultrasound scan to look at the Achilles tendon, use a scan to look at how stiff your calf muscles are, assess your body composition, complete a physical performance test and some questionnaires. Each participant will complete the measures during one clinic visit

Key Dates

First listed
Jul 24, 2026
Start date
Aug 31, 2026
Status verified
Jul 2026
Primary completion
Feb 29, 2028
Completion
Feb 29, 2028

Study Design

Enrollment
200 participants (estimated)

Arms

  • Arm: Sarcopenic
  • Arm: Non Sarcopenic

Primary Outcome Measure

Isometric plantarflexor strength testing [ Time Frame: Baseline ]

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