RePer-AGE: Reorganization of Visuo-cognitive Functions Based on Peripheral Vision With Aging

Sponsor
University Hospital, Grenoble
Study ID
NCT07727369
Status
Not Yet Recruiting

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Conditions

  • Aging
  • Cognition
  • Visual Perception

Eligibility Criteria

Sex
ALL
Age
18 Years - 85 Years
Healthy Volunteers
Accepted

Interventions

  • Psychophysical visual recognition tasks — BEHAVIORAL
    Computerized visual recognition tasks assessing the respective contributions of central and peripheral vision to scene recognition and predictive visual processing.
  • Ophthalmological assessment — DIAGNOSTIC_TEST
    Ophthalmological examinations including retinal sensitivity (Humphrey automated perimetry) and low-luminance visual acuity.
  • Functional magnetic resonance imaging (fMRI) — DIAGNOSTIC_TEST
    Functional MRI performed during psychophysical visual recognition tasks to assess brain activity associated with visual recognition and predictive visual processing.

Study Details

The RePer-AGE study investigates how central and peripheral vision contribute to visual recognition and how these mechanisms change with normal aging. The study is based on the hypothesis that peripheral vision provides rapid global information that supports visual recognition through predictive mechanisms. Healthy young adults (18-30 years) and older adults (60-85 years) will undergo visual psychophysical testing, ophthalmological examinations, and, for a subset of participants, functional magnetic resonance imaging (fMRI). The results are expected to improve our understanding of age-related changes in visuo-cognitive functions and provide reference data for future studies on age-related visual disorders.

Key Dates

First listed
Jul 27, 2026
Start date
Sep 1, 2026
Status verified
Jul 2026
Primary completion
Mar 31, 2030
Completion
Sep 30, 2030

Study Design

Enrollment
160 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Psychophysics and Ophthalmology
    Participants undergo psychophysical visual recognition tasks together with ophthalmological examinations, including retinal sensitivity assessment by automated perimetry and low-luminance visual acuity testing.
  • Experimental: Psychophysics and Functional MRI
    Participants undergo psychophysical visual recognition tasks while functional magnetic resonance imaging (fMRI) is performed to investigate the neural mechanisms underlying visual recognition and predictive processing.

Primary Outcome Measure

Behavioral performance during scene categorization tasks [ Time Frame: Baseline (single experimental session) ]

Central Contacts

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