Endothelial Extracellular Vesicles as Biomarkers of Endothelial Activation in Pregnant Women With Hypertensive Disorders of Pregnancy

Sponsor
Josip Juraj Strossmayer University of Osijek
Study ID
NCT07728656
Status
Recruiting
Apply to this trial

Conditions

  • Gestational Hypertension
  • Hypertensive Disorder of Pregnancy
  • Preeclampsia

Eligibility Criteria

Sex
FEMALE
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Study Details

Hypertensive disorders of pregnancy are associated with endothelial dysfunction and increased maternal and fetal morbidity. Endothelial extracellular vesicles (EEVs) have emerged as promising biomarkers of endothelial activation; however, their relationship with blood pressure and endothelial function during pregnancy remains incompletely understood. This observational case-control study aims to compare circulating EEV concentrations between normotensive pregnant women and pregnant women with hypertensive disorders of pregnancy. The study will also investigate the associations between EEV levels, blood pressure, microvascular endothelial function assessed by laser Doppler flowmetry, and circulating biomarkers of endothelial activation. The findings may improve understanding of endothelial injury during pregnancy and support the development of non-invasive biomarkers for early detection and monitoring of hypertensive disorders of pregnancy.

Key Dates

First listed
Jul 27, 2026
Start date
Apr 1, 2026
Status verified
Jun 2026
Primary completion
Apr 30, 2029
Completion
Sep 30, 2029

Study Design

Enrollment
80 participants (estimated)

Arms

  • Arm: Normotensive Pregnancy
    Pregnant women with normal blood pressure and uncomplicated singleton pregnancy.
  • Arm: Hypertensive Disorders of Pregnancy
    Pregnant women diagnosed with hypertensive disorders of pregnancy, including gestational hypertension or preeclampsia, according to current clinical guidelines.

Primary Outcome Measure

Plasma endothelial extracellular vesicle concentration [ Time Frame: Baseline ]

Central Contacts

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