Early Cognitive Interventions in Digital Format for Cancer Survivors

Sponsor
Biogipuzkoa Health Research Institute
Study ID
NCT07729969
Status
Recruiting
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Conditions

  • Cancer
  • Cognitive Change
  • Cognitive Impairment

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Computerized cognitive treatment — BEHAVIORAL
    Online exercises that target the following functions: attention, processing speed, memory, spatial orientation, interpersonal skills and intelligence. Participants will follow an online cognitive training with the BrainHQ program for 10 weeks. Patients will complete exercises that target attention, executive function, memory and processing speed. They will be asked to train approximately 30 minutes per BrainHQ session, 5 times per week for 10 weeks, a total of 25 hours. Training progresses in an adaptive way, based on the progression of the participant.
  • Virtual reality cognitive training — BEHAVIORAL
    A library of 15 cognitive exercises developed in virtual reality to train and monitor specific cognitive functions (memory, attention, task flexibility, information processing, orientation, and problem-solving) and motor control. Participants will follow a virtual reality cognitive training with the Enhance VR program for 10 weeks. Patients will complete exercises that target attention, executive function, memory and processing speed. Participants will be asked to train approximately 30 minutes per Enhance VR session, 4 times per week for 10 weeks, a total of 20 hours. Training progresses in an adaptive way, based on the progression of the participant.

Study Details

The aim of this study is to evaluate the usability and effectiveness of two professionally supervised home-based cognitive training interventions as part of an early rehabilitation protocol for cancer-related cognitive impairment. Participants will be randomized to one of the two intervention arms (computerized cognitive intervention or virtual reality cognitive intervention) or to the control group. Participants of the intervention groups will be assessed before and after the 10 weeks intervention or at equivalent time points for the control group. Comparisons between experimental and control participants, and between the participants in the two intervention arms, will be carried out to see which intervention is most effective and accepted.

Key Dates

First listed
Jul 28, 2026
Start date
Jun 8, 2026
Status verified
Jul 2026
Primary completion
Apr 30, 2028
Completion
Apr 30, 2028

Study Design

Enrollment
110 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE

Arms

  • Experimental: Computerized cognitive training - BrainHQ
    The arm will follow the cognitive training program BrainHQ.
  • Experimental: Virtual Reality cognitive training - Enhance VR
    The arm will follow the cognitive training program Enhance VR.
  • No Intervention: Control Group
    The arm will receive usual care with no cognitive intervention

Primary Outcome Measure

Change in Perceived Cognitive Function [ Time Frame: Baseline (before randomization and intervention), after completion of the 10-week intervention, and 1 year after completion of the intervention. ]

Central Contacts

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