Sarcopenia Screening in Advanced Coxarthrosis: The SARCO-COX Study

Sponsor
Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Study ID
NCT07734129
Status
Not Yet Recruiting

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Conditions

  • Coxarthrosis
  • Sarcopenia

Eligibility Criteria

Sex
ALL
Age
65 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Intensive Physical Rehabilitation — BEHAVIORAL
    Participants with sarcopenia assigned to the intervention group will undergo a supervised group physical rehabilitation program starting 6 months after total hip arthroplasty. The program consists of 1-hour sessions conducted twice weekly for 2 months and includes warm-up stretching exercises (10 minutes), 30 minutes of aerobic cycling, 15 minutes of upper and lower limb strengthening exercises, and a 5-minute cool-down with stretching and relaxation.
  • Preoperative Sarcopenia Screening — DIAGNOSTIC_TEST
    Participants will undergo preoperative screening for sarcopenia using the SARC-F questionnaire, handgrip strength measured by dynamometry, gait speed, and skeletal muscle index assessed by bioelectrical impedance analysis to identify sarcopenia before elective total hip arthroplasty.

Study Details

The SARCO-COX study evaluates whether screening for sarcopenia (loss of muscle strength and mass) in adults aged 65 years or older with advanced hip osteoarthritis, followed by a structured postoperative exercise program, improves recovery after total hip replacement surgery compared with standard care. Participants will undergo assessments of muscle strength, muscle mass, physical function, pain, and quality of life before surgery and during follow-up. Blood samples and a small muscle biopsy obtained during the planned surgery will be analyzed to study biomarkers related to muscle health. A total of 150 people are expected to participate in this study. Participants will be divided into three groups: * Group 1: People with sarcopenia who will take part in an exercise programme following surgery. * Group 2: People with sarcopenia who will receive the usual care and follow-up after their surgery. * Group 3: people without sarcopenia who are undergoing surgery and will receive the usual care and follow-up. The study aims to determine whether early identification and targeted rehabilitation of sarcopenia can improve functional outcomes and quality of life after hip replacement.

Key Dates

First listed
Jul 29, 2026
Start date
Jul 1, 2026
Status verified
Jul 2026
Primary completion
Sep 1, 2026
Completion
Sep 1, 2029

Study Design

Enrollment
150 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SCREENING

Arms

  • Experimental: Group 1 - Patients with Sarcopenia who perform physical training
    Patients with preoperative SAR who will undergo an intervention intensive post-surgical group physical therapy, starting 6 months after surgery.
  • Experimental: Group 2 - Patients with Sarcopenia who do not perform physical training.
    Patients with preoperative SAR who will be treated with standard postoperative therapy.
  • No Intervention: Group 3 - Control patients.
    Subjects in the same age range and sex without preoperative SAR will be recruited and will be treated with standard post-surgical therapy.

Primary Outcome Measure

Manual Grip Strength [ Time Frame: Baseline (3 months pre-surgery), 6 months, 12 months, 18 months, and 24 months post-surgery. ]

Central Contacts

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