Mechanisms Underlying Late-Life Prolonged Grief Disorder

Part of paid clinical trials in Milwaukee, Wisconsin.

Sponsor
Medical College of Wisconsin
Study ID
NCT07738133
Status
Not Yet Recruiting

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Conditions

  • Prolonged Grief Disorder

Eligibility Criteria

Sex
ALL
Age
40 Years - 89 Years
Healthy Volunteers
Not accepted

Interventions

  • Iyengar Yoga — BEHAVIORAL
    Participants will engage in 10 weekly IY classes
  • Health Education Control — BEHAVIORAL
    Participants will engage in 10 weekly socialization control group sessions
  • Waitlist Control to Crossover — OTHER
    Upon Step 1 study completion (week 10), participants in this group who continue to meet PGD criteria on the SCIP will enter Step 2 phase

Study Details

After losing a loved one, most successfully navigate acute grief and adapt to the loss within about 1 year, but in about 10%, prolonged grief disorder (PGD) ensues. This study is anticipated to provide novel evidence regarding the neurobiological mechanisms of PGD in older adults. The biological alterations identified here could provide targets to elucidate how currently available therapies work and inform novel mechanism-based interventions for treating late-life PGD.

Key Dates

First listed
Jul 31, 2026
Start date
Jan 31, 2027
Status verified
Jul 2026
Primary completion
Jan 31, 2031
Completion
Jun 30, 2031

Study Design

Enrollment
126 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER

Arms

  • Experimental: Yoga
    Participants will engage in 10 weekly IY classes
  • Active Comparator: Socialization Control
    Participants will engage in 10 weekly socialization control group sessions
  • Other: Waitlist Control
    Waitlist Control

Primary Outcome Measure

Score on the Prolonged Grief 13-Revised (PG-13-R) scale [ Time Frame: Baseline through study completion, up to 10 weeks ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Medical College of WisconsinMilwaukeeWisconsin53226
Keri Hainsworth, PhD
[email protected]
414-852-9046

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Medical College of Wisconsin· Milwaukee, WI

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