Dentin Hypersensitivity Reduction Efficacy Clinical

Conditions

• Dental Hypersensitivity

Eligibility Criteria

Sex

ALL

Age

18 Years - 70 Years

Healthy Volunteers

Accepted

Interventions

• 0.454% stannous fluoride toothpaste — DRUG
  brush twice daily (morning and evening) Duration of exposure: one (1) minute
• 5% potassium nitrate — DRUG
  Brush twice daily (morning and evening) Duration of exposure: one (1) minute
• 0.76% sodium monofluorophosphate — DRUG
  Brush twice daily (morning and evening) Duration of exposure: one (1) minute

Study Details

The objective of this study is to assess clinical efficacy of a toothpaste containing stannous fluoride (Colgate-Palmolive Company, New York, NY, USA) to provide dental hypersensitivity relief (tactile and air blast) in comparison to commercially available potassium-based desensitizing toothpaste (Senodyne Extra Whitening Toothpaste, GasoSmithKline Co., UK) and commercially available non-desensitizing toothpaste (Colgate Cavity Protection Toothpaste, Colgate-Palmolive Company, New York, NY, USA) over a seven day study period

Key Dates

First listed

Jul 31, 2026

Start date

Nov 26, 2018

Status verified

Jul 2026

Primary completion

Dec 8, 2018

Completion

Dec 8, 2018

Study Design

Enrollment

116 participants (actual)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• Experimental: Test 1 toothpaste
• Active Comparator: Test 2 toothpaste
• Active Comparator: Test 3 toothpaste

Primary Outcome Measure

Tactile Sensitivity using the Yeaple Electronic Force Sensing Probe [ Time Frame: baseline, 1 day, 3 day, 7 day ]

Locations (1)

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