Validation of a Deep Learning Tool for Opportunistic Osteoporosis Screening Using Routine Non-Contrast CT Scans

Sponsor
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Study ID
NCT07739628
Status
Enrolling By Invitation

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • DeepBMD model for osteoporosis risk screening — DIAGNOSTIC_TEST
    The DeepBMD model is applied to routine chest or abdominal CT scans to identify patients at high risk for osteoporosis. This is a non-invasive image analysis used solely for screening and recruitment purposes, not as a therapeutic intervention.

Study Details

The goal of this clinical trial is to test if an artificial intelligence (AI) tool called DeepBMD can accurately identify people at high risk for osteoporosis using routine chest or abdomen CT scans. The main questions it aims to answer are: 1. Can the DeepBMD tool correctly identify people who have osteoporosis compared to the standard bone density test, dual-energy X-ray absorptiometry (DXA)? 2. Is it practical to use this AI tool in real-world hospital settings to find and contact high-risk patients? Researchers will use the DeepBMD tool to analyze existing CT scans. If the tool flags a patient as high risk, researchers will call them to invite them for a standard bone density test (DXA). Participants will: 1. Have their existing chest or abdomen CT scan analyzed by the DeepBMD AI tool; 2. Receive a phone call from the research team if identified as high risk; 3. Visit the clinic for a free standard bone density test (DXA) if they agree to participate.

Key Dates

First listed
Jul 31, 2026
Start date
Jul 31, 2026
Status verified
Jul 2026
Primary completion
Aug 31, 2026
Completion
Sep 30, 2026

Study Design

Enrollment
100 participants (estimated)

Arms

  • Arm: High-risk patients for osteoporosis identified by DeepBMD model
    Patients who underwent routine chest or abdominal CT scans and were identified as high risk for osteoporosis by the DeepBMD AI model. These participants will be contacted via telephone, invited to the clinic, and undergo a free DXA scan to verify bone mineral density.

Primary Outcome Measure

Diagnostic performance of DeepBMD model for osteoporosis screening [ Time Frame: Concurrent with the DXA validation visit following the CT analysis (within 7 days). ]

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