A Novel Smartphone Application for Helping Teens Stop Vaping, QuitQuest Vaping R01

Part of paid clinical trials in Seattle, Washington.

Sponsor
Fred Hutchinson Cancer Center
Study ID
NCT07739706
Status
Not Yet Recruiting

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Conditions

  • Tobacco-Related Carcinoma

Eligibility Criteria

Sex
ALL
Age
13 Years - 17 Years
Healthy Volunteers
Accepted

Interventions

  • Smartphone Application-based Intervention — BEHAVIORAL
    Use QuitQuest app
  • Smartphone Application-based Intervention — BEHAVIORAL
    Use SFTQV app
  • Survey Administration — OTHER
    Ancillary studies
  • Interview — OTHER
    Ancillary studies

Study Details

This clinical trial compares a novel smartphone application (app) called QuitQuest to the National Cancer Institute's (NCI's) SmokefreeTeenQuitVaping (SFTQV) app in helping teens stop vaping. Despite recent declines, data shows that 8.5% of middle school (grades 6-8) and 18.1% of high school (grades 9-12) students in the United States (US) used electronic nicotine delivery systems (ENDS; variously known as vaping, electronic \[e\]-cigarettes, e-cigs, mods, and tank systems that contain nicotine). Use of any tobacco product during adolescence increases risk for lifelong nicotine addiction. ENDS use, in particular, leads to severe asthma attacks, e-cigarette or vaping product use-associated lung injury (EVALI), exposure to multiple lung irritants, including volatile organic compounds, and lasting harm to adolescent brain development. Despite evidence of potential long-term harms from ENDS, to date there have been limited evidence-based therapeutic options for ENDS cessation for adolescents and young adults. Traditional methods for delivering adolescent ENDS cessation interventions (e.g., quitlines and clinics) have limited reach. QuitQuest utilizes Acceptance and Commitment Therapy (ACT), a psychological intervention that uses acceptance and mindfulness strategies, together with commitment and behavior change strategies, to increase psychological flexibility, reduce distress, and promote behavior change through mechanisms that include cultivating acceptance of internal experience and aligning behavior with personal values. The SFTQV program is based on the US Clinical Practice Guidelines, offering practical advice and support via an app delivery format. The QuitQuest app may work better than the SFTQV app in increasing vape quit rates among teens.

Key Dates

First listed
Jul 31, 2026
Start date
Dec 1, 2026
Status verified
Jul 2026
Primary completion
Mar 31, 2030
Completion
Mar 31, 2031

Study Design

Enrollment
1,072 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION

Arms

  • Experimental: Arm I (QuitQuest app)
    Participants download and install the QuitQuest app for 12 months on study.
  • Active Comparator: Arm II (SFTQV app)
    Participants utilize the NCI's SFTQV app for 12 months on study.

Primary Outcome Measure

Self-reported 30-day point prevalence abstinence (PPA) from electronic nicotine delivery systems (ENDS) use [ Time Frame: At 6 months post-randomization ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Fred Hutch/University of Washington Cancer ConsortiumSeattleWashington98109
Jonathan Bricker, PhD
[email protected]
206-667-5074
Jonathan Bricker, PhD (PRINCIPAL_INVESTIGATOR)

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By research site
Fred Hutch/University of Washington Cancer Consortium· Seattle, WA

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