Role of Progesterone Membrane Receptors in the Pathogenesis of Preeclampsia

Sponsor
Samsun University
Study ID
NCT07745036
Status
Recruiting
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Conditions

  • Preeclampsia
  • Preeclampsia Complications

Eligibility Criteria

Sex
FEMALE
Age
18 Years - 45 Years
Healthy Volunteers
Accepted

Study Details

Preeclampsia is a pregnancy-specific hypertensive disorder and remains a leading cause of maternal and perinatal morbidity and mortality worldwide. Although abnormal placentation, impaired trophoblast invasion, endothelial dysfunction, and immune dysregulation have been implicated in its pathogenesis, the underlying molecular mechanisms are not fully understood. Progesterone plays a critical role in the maintenance of pregnancy through both classical nuclear receptors and membrane-associated progesterone receptors. Emerging evidence suggests that progesterone membrane receptors, including progesterone receptor membrane component 1 (PGRMC1), progesterone receptor membrane component 2 (PGRMC2), and members of the progestin and adipoQ receptor (PAQR) family, may regulate trophoblast invasion, placental development, and inflammatory responses. This study aims to compare the placental expression levels of PGRMC1, PGRMC2, and PAQR family receptors between women with preeclampsia and healthy pregnant controls and to investigate their potential role in the pathophysiology of preeclampsia.

Key Dates

First listed
Aug 4, 2026
Start date
Sep 1, 2025
Status verified
Jul 2026
Primary completion
Jan 1, 2027
Completion
Jan 15, 2027

Study Design

Enrollment
90 participants (estimated)

Arms

  • Arm: preeclampsia group
    Preeclampsia group
  • Arm: Control Group
    Healty Control Group

Primary Outcome Measure

Placental expression levels of progesterone membrane receptors (PGRMC1, PGRMC2, and PAQR family receptors) [ Time Frame: At delivery ]

Central Contacts

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