Value of Biomarkers of Brain Injury for Predicting Psycho-cognitive Sequelae Secondary to Sepsis: a Prospective Multicenter Study

Sponsor
Assistance Publique - Hôpitaux de Paris
Study ID
NCT07746050
Status
Not Yet Recruiting

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Conditions

  • Sepsis
  • Septic Shock

Eligibility Criteria

Sex
ALL
Age
18 Years - 80 Years
Healthy Volunteers
Not accepted

Interventions

  • Serum — BIOLOGICAL
    Neurofilament light chain NfL, brain-derived tau, GFAP, UCHL1, p-tau217, s100B, neurone specific enolase NSE, sTREM2, YKL-40

Study Details

To evaluate the value of biomarkers of neuronal and glial injury for predicting cognitive impairment (memory impairment assessed by a MoCA score \< 26/30) at 3 months in patient admitted in the intensive care unit for a sepsis or a septic shock.

Key Dates

First listed
Aug 4, 2026
Start date
Sep 30, 2026
Status verified
Jul 2026
Primary completion
May 31, 2028
Completion
Aug 31, 2028

Study Design

Enrollment
210 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC

Primary Outcome Measure

Cognitive function impairment assessed by the Montreal Cognitive Assessment (MoCA) score at 3 months [ Time Frame: 3 months ]

Central Contacts

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