North Jersey Community Research Initiative (NJCRI) Study on Transgender Liver Health

Conditions

• HEPATITIS C (HCV)

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Accepted

Study Details

Primary Objective: Assess disparities in liver health outcomes among transgender individuals on GAHT by evaluating liver function markers (transaminases, bilirubin levels, etc), as well as liver elasticity and presence of liver steatosis or Nonalcoholic Fatty Liver Disease (NAFLD) through FibroScan. A total of 60 participants will be recruited throughout the study, with a ratio of 1:1 between transgender participants who have been on GAHT more than 6 months ( = or \> 182 days), and transgender participants who have been on GAHT for less than 6 months ( \< 181 days) at the start of the study. Secondary Objectives: Assess liver health-related risk factors (e.g. obesity, alcohol consumption) in transgender population. Investigate the association between specific hormone regimens and liver function in transgender individuals. Explore potential modifiers of liver health outcomes, such as age, social barriers determinants of health, duration of hormone therapy and adherence to medical guidelines. Change in Quality of Life from baseline to last study visit.

Key Dates

First listed

Aug 5, 2026

Start date

Mar 15, 2025

Status verified

Jul 2026

Primary completion

Mar 15, 2027

Completion

Mar 15, 2027

Study Design

Enrollment

60 participants (estimated)

Arms

• Arm: Transgender >6 months on GAHT and Transgender <6 months on GAHT
  A total of 60 participants will be recruited throughout the study, with a ratio of 1:1 between transgender participants who have been on GAHT more than 6 months ( = or \> 182 days), and transgender participants who have been on GAHT for less than 6 months ( \< 181 days) at the start of the study

Primary Outcome Measure

Assess disparities in liver health outcomes among transgender individuals [ Time Frame: Baseline through December 2027 ]

Locations (1)

Find similar trials in Newark, NJ

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