Impact of Smoking on Immune Responses in Peri-implant Health and Disease

Sponsor
Gazi University
Study ID
NCT07750171
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
21 Years - 75 Years
Healthy Volunteers
Accepted

Study Details

Peri-implant diseases are inflammatory conditions affecting the gums and bone around dental implants. Peri-implant mucositis causes inflammation in the gums, while peri-implantitis can also lead to bone loss and, in severe cases, implant failure. Smoking is an important risk factor for these conditions because it may change how the immune system responds to inflammation and infection. This study will compare smokers and non-smokers with healthy dental implants, peri-implant mucositis, or peri-implantitis. Fluid samples will be collected from around the implants to measure proteins involved in inflammation, healing, and immune responses. The aim is to better understand how smoking affects the body's response to peri-implant diseases and to identify biological markers that may help assess disease risk and severity in the future.

Key Dates

First listed
Aug 6, 2026
Start date
Jun 1, 2026
Status verified
Aug 2026
Primary completion
Oct 1, 2026
Completion
Dec 1, 2026

Study Design

Enrollment
216 participants (estimated)

Arms

  • Arm: Non-Smokers With Peri-Implant Health
    Participants who do not smoke and have clinically healthy peri-implant tissues.
  • Arm: Non-Smokers With Peri-Implant Mucositis
    Participants who do not smoke and have peri-implant mucositis.
  • Arm: Non-Smokers With Peri-Implantitis
    Participants who do not smoke and have peri-implantitis.
  • Arm: Smokers With Peri-Implant Health
    Participants who smoke and have clinically healthy peri-implant tissues.
  • Arm: Smokers With Peri-Implant Mucositis
    Participants who smoke and have peri-implant mucositis.
  • Arm: Smokers With Peri-Implantitis
    Participants who smoke and have peri-implantitis

Primary Outcome Measure

Peri-implant crevicular fluid levels of Th1/Th2-, M1/M2-, and B-cell-related immune markers [ Time Frame: At a single study visit ]

Central Contacts

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