Long-term Effects of Avocado Consumption on Health in Pre-diabetic Individuals

Sponsor
Maastricht University Medical Center
Study ID
NCT07752225
Status
Not Yet Recruiting

Notify me when recruiting opens

Save your spot on the interest list for this study. We'll keep your details with this study so our team can follow up when recruiting opens.

Not yet recruiting

Add your contact details and location so we can keep your interest tied to this study.

Conditions

  • Brain Health
  • Brain Insulin Sensitivity
  • Cerebral Blood Flow
  • Food Reward
  • Obesity & Overweight
  • Prediabetes
  • Satiety and Food Intake
  • Vascular Function

Eligibility Criteria

Sex
ALL
Age
40 Years - 75 Years
Healthy Volunteers
Not accepted

Interventions

  • Avocados — DIETARY_SUPPLEMENT
    Participants need to consume 1 avocado a day for 12 weeks.

Study Details

Primary aim of the study is to assess the effect of 12-week daily avocado consumption on cerebral blood flow and markers of cardio- and vascular health in both, the periphery and the brain, in pre-diabetic individuals with overweight or obesity. Secondary objective is to assess the effects of 12-week daily avocado consumption on brain insulin sensitivity after intranasal insulin delivery, vascular function, markers of metabolic health, cognition, and psychological well-being. For that purpose a total of 34 men and women between the ages of 40-75 years old, will participate in a randomised crossover intervention study.

Key Dates

First listed
Aug 7, 2026
Start date
Sep 1, 2026
Status verified
Aug 2026
Primary completion
Jun 30, 2028
Completion
Aug 31, 2028

Study Design

Enrollment
34 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION

Arms

  • Experimental: Avocado intervention in the first period of the study (Arm 1)
    Both arms receive the intervention. Arm 1 is consuming 1 or no avocado a day for the first 12 weeks of the study.
  • Experimental: Avocado intervention in the second period of the study (Arm 2)
    Both arms receive the intervention but arm 2 is consuming 1 or no avocado a day for the last 12 weeks of the study.

Primary Outcome Measure

Cerebral Blod Flow (CBF) [ Time Frame: CBF will be assessed at baseline, after period 1 (after 12 weeks), and at the end of the study (after 32 weeks) ]

Central Contacts

Related Studies