Stroke Volume-based Fluid Resuscitation in AP

Part of paid clinical trials in Los Angeles, California.

Sponsor
University of Southern California
Study ID
NCT07756476
Status
Recruiting
Apply to this trial

Conditions

  • Acute Pancreatitis (AP)

Eligibility Criteria

Sex
ALL
Age
18 Years - 75 Years
Healthy Volunteers
Not accepted

Interventions

  • Lactated Ringer's — OTHER
    lactated ringer's in intervention is dosed based on changes in stroke volume versus a weight based strategy
  • Lactated Ringers Stroke Volume Based Dosing — OTHER
    Lactated Ringers Rate is based on changes in stroke volume

Study Details

The SUSTAIN Trial is a randomized control trial that allows for the control of aggressive hydration that is currently used in an inpatient setting, which can result is fluid overload in certain patients. With the impression that changes in stroke volume in individual patient will further improve the outcome.

Key Dates

First listed
Aug 10, 2026
Start date
Mar 19, 2026
Status verified
Aug 2026
Primary completion
Mar 19, 2028
Completion
Sep 19, 2028

Study Design

Enrollment
80 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Group 1: Fluid Resuscitation in Stroke Volume with Leg Raise
    We suggest that changes in stroke volume on individual patients can further improve outcomes with fluid resuscitation and prevent fluid overload in the individuals with acute pancreatitis.
  • Other: Group 2: Moderate fluid resuscitation per body weight
    This arm is based on a past fluid resuscitation study, WATERFALL Study, where there was moderate fluid resuscitation in the setting of treatment for acute pancreatitis.

Primary Outcome Measure

SIRS Values at the 48 hours after enrollement [ Time Frame: 48 hours ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
University of Southern CaliforniaLos AngelesCalifornia90033
Jorge Zuniga, BS
[email protected]
3234420876
Jorge ZunigaGomez, BS
[email protected]
3234420876
Ohio State UniversityColumbusOhio43210-

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