The Effects of Tyrosol and Creatine on Exercise Performance and Cognition in Healthy Adults

Part of paid clinical trials in Tampa, Florida.

Sponsor
Applied Science & Performance Institute
Study ID
NCT07756658
Status
Not Yet Recruiting

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Conditions

  • Cognition
  • Creatine
  • Endurance Performance
  • Mood
  • Tyrosol

Eligibility Criteria

Sex
MALE
Age
20 Years - 55 Years
Healthy Volunteers
Accepted

Interventions

  • Tyrosol — DIETARY_SUPPLEMENT
    phenolic compound found in olive oil
  • Creatine Monohydrate — DIETARY_SUPPLEMENT
    chemical produced naturally by the body used to rapidly regenerate ATP
  • Resistant Dextrin — DIETARY_SUPPLEMENT
    A type of soluble dietary fiber that is resistant to digestion in the small intestine. It is a byproduct of the starch hydrolysis process, where starch is broken down into smaller chains of glucose molecules

Study Details

This study will be a randomized, double-blind, placebo-controlled trial. It will be conducted over a 8-week intervention investigating the effects of creatine (5g Creatine monohydrate); placebo control (5g resistant dextrin), and a combination group containing both creatine and tyrosol (5g creatine monohydrate + 150mg tyrosol/day). Endurance, strength, cognition, and fatigue resistance will be examined through repeated strength and endurance testing (described below). Participants who pass initial screening will be invited on-site for day one (Visit 1) of testing where they will proceed with a series of tests which will include the following: (1) body composition; (2) mood and cognitive testing; (3) full-body strength testing; (4) 5RM (repetition maximum) bench press, leading to multiple sets of bench press (based on the previous weight) completed to failure; (5) finally, a time to exhaustion endurance test will be conducted followed by (6) repeat cognitive testing. After the 8-week supplementation period (\~56-60 days), all original measures will be repeated as before in the same order (Visit 2). Approximately 24 hours later (Visit 3) participants will complete a questionnaire for muscle soreness remotely, and again at 48 hours post-Visit 2 (visit 4).

Key Dates

First listed
Aug 11, 2026
Start date
Aug 17, 2026
Status verified
Aug 2026
Primary completion
Dec 17, 2026
Completion
Dec 17, 2026

Study Design

Enrollment
60 participants (estimated)
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
TREATMENT

Arms

  • Experimental: Tyrosol and Creatine
    150mg Tyrosol (administered as 1 capsule, containing 150mg/capsule) + 5g of Creatine Monohydrate powder; taken daily
  • Experimental: Creatine + Placebo
    5g Creatine Monohydrate powder + 150mg Resistant dextrin capsules (administered as 1 capsule, containing 150mg/capsule) (placebo); taken daily
  • Experimental: Placebo + placebo
    5g of resistant dextrin powder (placebo) + 150mg Resistant dextrin capsules (administered as 1 capsule, containing 150mg/capsule) (placebo); taken daily

Primary Outcome Measure

Mid Thigh Pull [ Time Frame: Performed one time at baseline (visit 1) and at day 56 (visit 2) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Applied Science and Performance InstituteTampaFlorida33634
Eric Sikorski, PhD
[email protected]
8138678888
Gabe Wilson, PhD
[email protected]
8138678888
Eric Sikorski, PhD (PRINCIPAL_INVESTIGATOR)
Gabe Wilson, PhD (SUB_INVESTIGATOR)
Jacob Wilson, PhD (SUB_INVESTIGATOR)

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