Photodynamic Therapy For Onychomycosis

Part of paid clinical trials in Arlington, Texas.

Sponsor
The University of Texas Health Science Center, Houston
Study ID
NCT07756671
Phase
PHASE1
Status
Not Yet Recruiting

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Conditions

  • Onychomycosis of Toenail

Eligibility Criteria

Sex
ALL
Age
18 Years - 100 Years
Healthy Volunteers
Not accepted

Interventions

  • ALA 10% gel — DRUG
    ALA 10% gel will be applied under occlusion for 3 hours before PDT
  • PDT — DEVICE
    Participants will have illumination on the affected nail with RhodoLED® XL 635 nm red light at 37 J/cm² at 5 inches for 13.5 minutes.
  • Urea — DRUG
    Participants will have 20% urea applied to affected nail daily for 2 weeks before start of treatment

Study Details

The purpose of this study is clinical and mycological clearance of onychomycosis using photodynamic therapy (PDT) with aminolevulinic acid (ALA) 10% gel at 6 months, 3 months, 9 months and 12 months

Key Dates

First listed
Aug 11, 2026
Start date
Aug 10, 2026
Status verified
Aug 2026
Primary completion
Jun 30, 2027
Completion
Dec 31, 2027

Study Design

Enrollment
5 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Photodynamic Therapy

Primary Outcome Measure

Number of participants that show Clinical clearance of onychomycosis [ Time Frame: 6 months after treatment ]

Central Contacts

Locations (3)

FacilityCityStateZIPSite coordinators
Arlington Center for DermatologyArlingtonTexas76011
Luke Moore, MBTS, BS
[email protected]
(817) 795-7546
Houston SkinHoustonTexas77004
Stephen Tyring, MD, PhD, MBA
[email protected]
(281) 333-3376
Luke Moore
[email protected]
(817) 795-7546
Houston SkinWebsterTexas77598
Stephen Tyring, MD, PhD, MBA
[email protected]
(281) 333-3376
Luke Moore
[email protected]
(817) 795-7546

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