Neurocomputational Dynamics of Cooperation

Part of paid clinical trials in Pittsburgh, Pennsylvania.

Sponsor
University of Pittsburgh
Study ID
NCT07759973
Status
Not Yet Recruiting

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Conditions

  • Interpersonal Conflict
  • Mental Health
  • Personality Disorder
  • Social Cognition

Eligibility Criteria

Sex
ALL
Age
18 Years - 100 Years
Healthy Volunteers
Accepted

Interventions

  • Social Learning Task Battery, Clinical Cohort — BEHAVIORAL
    In the primary study task, participants engage in a modified iterative trust game. The task is completed in the fMRI scanner and takes about 35 minutes. Participant choices earn feedback in the form of monetary gains or losses. All participants are debriefed on the motivation behind the task at the end of their visit.
  • Social Learning Task Battery, Online Cohort — BEHAVIORAL
    In the primary study task, participants engage in a modified iterative trust game. Participant choices earn feedback in the form of monetary gains or losses. All participants are debriefed on the motivation behind study task at the end of their visit.

Study Details

The purpose of this study is to understand brain function, how people make decisions when they interact with others, and how brain function and behavior relate to personality traits.

Key Dates

First listed
Aug 12, 2026
Start date
Sep 1, 2026
Status verified
Aug 2026
Primary completion
Jun 30, 2031
Completion
Jun 30, 2031

Study Design

Enrollment
1,612 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Online Cohort
    The online cohort will include 718 adults ages 18-100 who will complete 1) a battery of behavioral tasks designed to assess social learning and mentalizing abilities, and 2) self-report measures assessing personality, externalizing symptoms, interpersonal functioning, and psychopathology.
  • Experimental: Clinical Cohort
    The study will enroll up to 416 clinical-cohort participants, with an anticipated final eligible sample of 239 adults ages 20-60 who will complete 1) a structured clinical interview and neuropsychological assessments, 2) self-report measures assessing personality, externalizing symptoms, interpersonal functioning, and psychopathology, 3) lab-based tasks designed to assess social learning and mentalizing abilities while monitoring physiological responding with Biopac, 4) task-based fMRI, 5) 21-day ecological momentary assessment (EMA) protocol, and 6) additional self-report questionnaires at three yearly follow-ups. The investigators expect to enroll 416 participants for the start of the protocol to yield 239 final eligible participants to complete fMRI and EMA.
  • No Intervention: Informants
    Additionally, 2 informants (ages 18+) for each participant will be recruited to complete self-report measures, one of whom will also enroll in EMA.

Primary Outcome Measure

Participant-level Coaxing Score [ Time Frame: During behavioral task visit at study baseline (clinical cohort) or during single online study session (online cohort) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Pittsburgh, Bellefield TowersPittsburghPennsylvania15213
Michelle M Berry, MPS
[email protected]
424-380-1194
Amanda Collier, BS
[email protected]
412-901-2938
Timothy A Allen, PhD (PRINCIPAL_INVESTIGATOR)
Alexandre Dombrovski, MD (SUB_INVESTIGATOR)

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By research site
University of Pittsburgh, Bellefield Towers· Pittsburgh, PA

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