A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEF

Part of paid clinical trials in Fairhope, Alabama.

Sponsor
AstraZeneca
Study ID
NCT07761117
Phase
PHASE3
Status
Recruiting
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Conditions

  • Heart Failure With Mildly Reduced Ejection Fraction (HFmrEF)
  • Heart Failure With Preserved Ejection Fraction (HFpEF)

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Elecoglipron — DRUG
    Elecoglipron tablet
  • Placebo — DRUG
    Placebo tablet

Study Details

This is a Phase III, randomized, double-blind, parallel-group, placebo-controlled, multicenter study to investigate CV outcomes with elecoglipron compared with placebo, in adults with heart failure with preserved ejection fraction (HFpEF)/heart failure with mildly reduced ejection fraction (HFmrEF), irrespective of T2DM status, and who are on background dapagliflozin in addition to other background standard of care.

Key Dates

First listed
Aug 12, 2026
Start date
Aug 24, 2026
Status verified
Sep 2026
Primary completion
Sep 3, 2029
Completion
Sep 3, 2029

Study Design

Enrollment
6,950 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Elecoglipron
    Elecoglipron tablet once daily
  • Active Comparator: Placebo
    Placebo matching Elecoglipron tablet once daily

Primary Outcome Measure

To evaluate the effect of elecoglipron compared with placebo in reducing the risk of CV death or HHF/urgent HF visit [ Time Frame: Up to 42 months ]

Central Contacts

Locations (118)

FacilityCityStateZIPSite coordinators
Research SiteFairhopeAlabama36532-
Research SiteAnchorageAlaska99508-
Research SiteGilbertArizona85295-
Research SiteSurpriseArizona85374-
Research SiteBeverly HillsCalifornia90211-
Research SiteHuntington BeachCalifornia92647-
Research SiteHuntington ParkCalifornia90255-
Research SiteLoma LindaCalifornia92354-
Research SiteLomitaCalifornia90717-
Research SiteMatherCalifornia95655-
Research SiteNorthridgeCalifornia91324-
Research SitePalo AltoCalifornia94304-
Research SiteReddingCalifornia96001-
Research SiteSan DiegoCalifornia92117-
Research SiteTarzanaCalifornia91356-
Research SiteColorado SpringsColorado80909-
Research SiteNew HavenConnecticut06519-
Research SiteBradentonFlorida34209-
Research SiteHallandaleFlorida33009-
Research SiteJacksonvilleFlorida32209-
Research SiteLakelandFlorida33813-
Research SiteMiamiFlorida33125-
Research SiteMiamiFlorida33144-
Research SiteMiamiFlorida33176-
Research SiteMiami LakesFlorida33014-
Research SiteMiami LakesFlorida33016-
Research SiteOcoeeFlorida34761-
Research SitePalmetto BayFlorida33157-
Research SiteRiverviewFlorida33578-
Research SiteAtlantaGeorgia30303-
Research SiteColumbusGeorgia31904-
Research SiteTuckerGeorgia30084-
Research SiteChampaignIllinois61822-
Research SiteChicagoIllinois60640-
Research SiteGurneeIllinois60031-
Research SiteMelrose ParkIllinois60160-
Research SiteMolineIllinois61265-
Research SiteNilesIllinois60714-
Research SiteRockfordIllinois61107-
Research SiteSchaumburgIllinois60173-
Research SiteWinfieldIllinois60190-
Research SiteIndianapolisIndiana46254-
Research SiteWaterlooIowa50701-
Research SiteLeavenworthKansas66048-
Research SiteWichitaKansas67214-
Research SiteOwensboroKentucky42301-
Research SiteBossier CityLouisiana71111-
Research SiteCovingtonLouisiana70433-
Research SiteLafayetteLouisiana70503-
Research SiteNew OrleansLouisiana70121-
Research SiteShreveportLouisiana71105-
Research SiteZacharyLouisiana70791-
Research SiteAnnapolisMaryland21401-
Research SiteBaltimoreMaryland21229-
Research SiteLanhamMaryland20706-
Research SiteOxon HillMaryland20745-
Research SiteBostonMassachusetts02114-
Research SiteBostonMassachusetts02118-
Research SiteNew BedfordMassachusetts02740-
Research SiteWorcesterMassachusetts01655-
Research SiteFlintMichigan48503-
Research SiteSouthfieldMichigan48075-
Research SiteSouthfieldMichigan48076-
Research SiteTroyMichigan48098-
Research SiteBridgetonMissouri63044-
Research SiteKansas CityMissouri64111-
Research SiteKansas CityMissouri64111-
Research SiteLincolnNebraska68510-
Research SiteBridgewaterNew Jersey08807-
Research SiteMillvilleNew Jersey08332-
Research SiteSewellNew Jersey08080-
Research SiteTrentonNew Jersey08690-
Research SiteVinelandNew Jersey08360-
Research SiteBrooklynNew York11220-
Research SiteBuffaloNew York14215-
Research SiteNew YorkNew York10001-
Research SiteNew YorkNew York10019-
Research SiteRosedaleNew York11422-
Research SiteThe BronxNew York10451-
Research SiteThe BronxNew York10455-
Research SiteChapel HillNorth Carolina27514-
Research SiteDurhamNorth Carolina27710-
Research SiteGreensboroNorth Carolina27401-
Research SiteStatesvilleNorth Carolina28677-
Research SiteWilmingtonNorth Carolina28401-
Research SiteFargoNorth Dakota58104-
Research SiteGrand ForksNorth Dakota58201-
Research SiteColumbusOhio43215-
Research SiteColumbusOhio43228-
Research SiteDaytonOhio45435-
Research SiteMaumeeOhio43537-
Research SiteOklahoma CityOklahoma73134-
Research SiteBethlehemPennsylvania18015-
Research SiteMediaPennsylvania19063-
Research SitePhiladelphiaPennsylvania19104-
Research SitePhiladelphiaPennsylvania19107-
Research SiteSmithfieldPennsylvania15478-
Research SiteYardleyPennsylvania19067-
Research SiteEast ProvidenceRhode Island02914-
Research SiteSpartanburgSouth Carolina29303-
Research SiteRapid CitySouth Dakota57701-
Research SiteDallasTexas75216-
Research SiteDeSotoTexas75115-
Research SiteEl PasoTexas79905-
Research SiteHoustonTexas77025-
Research SiteHoustonTexas77082-
Research SiteHumbleTexas77338-
Research SitePlanoTexas75093-
Research SiteSan AntonioTexas78231-
Research SiteSan AntonioTexas78257-
Research SiteTomballTexas77375-
Research SiteTylerTexas75701-
Research SiteVictoriaTexas77901-
Research SiteBurlingtonVermont05401-
Research SiteArlingtonVirginia22205-
Research SiteRedmondWashington98052-
Research SiteKingwoodWest Virginia26537-
Research SiteMorgantownWest Virginia26505-

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