Continuous Theta Burst Stimulation for Generalized Anxiety Disorder

Sponsor
Military Hospital 175
Study ID
NCT07770919
Status
Not Yet Recruiting

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Conditions

  • Generalized Anxiety Disorder

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Not accepted

Interventions

  • Continuous Theta Burst Stimulation of the Right Posterior Parietal Cortex — DEVICE
    Continuous theta burst stimulation (cTBS) is delivered to the right posterior parietal cortex (R-PPC) at 80% of the active motor threshold (AMT). Participants receive 10 treatment sessions over approximately 1 week, in addition to stable background pharmacotherapy.
  • Continuous Theta Burst Stimulation of the Right Dorsolateral Prefrontal Cortex — DEVICE
    Continuous theta burst stimulation (cTBS) is delivered to the right dorsolateral prefrontal cortex (R-DLPFC) at 80% of the active motor threshold (AMT). Participants receive 20 treatment sessions over approximately 4 weeks, in addition to stable background pharmacotherapy.

Study Details

This randomized clinical trial evaluates the effectiveness of continuous theta burst stimulation (cTBS) combined with background pharmacotherapy in patients with generalized anxiety disorder. Participants will be randomly assigned to receive cTBS targeting either the right posterior parietal cortex or the right dorsolateral prefrontal cortex. The study will compare changes in anxiety symptoms between the two treatment strategies and will also assess quality of life, sleep, cognitive function, electroencephalographic measures, and transcranial magnetic stimulation-electroencephalography measures.

Key Dates

First listed
Aug 18, 2026
Start date
Aug 31, 2026
Status verified
Aug 2026
Primary completion
Jun 30, 2028
Completion
Jun 30, 2028

Study Design

Enrollment
40 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: cTBS Right Posterior Parietal Cortex
    Participants receive continuous theta burst stimulation (cTBS) targeting the right posterior parietal cortex (R-PPC) in addition to background pharmacotherapy. The treatment course consists of 10 cTBS sessions delivered over approximately 1 week.
  • Experimental: cTBS Right Dorsolateral Prefrontal Cortex
    Participants receive continuous theta burst stimulation (cTBS) targeting the right dorsolateral prefrontal cortex (R-DLPFC) in addition to background pharmacotherapy. The treatment course consists of 20 cTBS sessions delivered over approximately 4 weeks.

Primary Outcome Measure

Change in Hamilton Anxiety Rating Scale (HAM-A) Total Score [ Time Frame: Baseline (T0) to end of treatment (T4), assessed 24-72 hours after the final treatment session ]

Central Contacts

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