Hippocampal Temporal Interference Stimulation for Memory and Dual-Task Postural Control in Older Adults With Mild Cognitive Impairment

Sponsor
Shanghai University of Sport
Study ID
NCT07771036
Status
Recruiting
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Conditions

  • Mild Cognitive Impairment (MCI)

Eligibility Criteria

Sex
ALL
Age
65 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Temporal Interference Stimulation — DEVICE
    Transcranial temporal interference stimulation (TIS) is a noninvasive brain stimulation technique. In this randomized crossover trial, each participant receives two sessions in random order: one active 40 Hz TIS session targeting the left hippocampus and one sham session, with at least 7 days between sessions. Each session lasts 20 minutes. Outcome measures include memory tests, dual-task postural control assessments, and fMRI scans, conducted before and immediately after each session.

Study Details

This trial aims to investigate whether a single session of 40 Hz hippocampal temporal interference stimulation can improve memory function and dual-task postural control among older adults with mild cognitive impairment (MCI). The primary research questions to be addressed are as follows: * Can 40 Hz hippocampal temporal interference stimulation boost memory test performance in older adults with MCI? * Can 40 Hz hippocampal temporal interference stimulation improve walking and balance ability under dual-task conditions in older adults with MCI? Researchers will compare active 40 Hz hippocampal temporal interference stimulation against sham stimulation to identify whether this intervention yields positive immediate effects on memory function and dual-task postural control. Participants will be required to: * Attend three laboratory visits over approximately three weeks, and receive one session of active stimulation and one session of sham stimulation in random order, with an interval of at least seven days between the two stimulation visits; * Complete memory and motor function assessments before and after each stimulation session; * Undergo functional magnetic resonance imaging (fMRI) scans to detect changes in brain activity.

Key Dates

First listed
Aug 18, 2026
Start date
Jul 30, 2026
Status verified
Aug 2026
Primary completion
Jul 15, 2027
Completion
Jul 30, 2027

Study Design

Enrollment
21 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT

Arms

  • Experimental: TIs Arm
    Participants receive a single 20-minute session of active 40 Hz temporal interference stimulation (TIS) targeting the left hippocampus. In this randomized crossover design, each participant also undergoes a sham session on a separate visit, with at least 7 days between sessions. Memory, dual-task postural control, and fMRI assessments are conducted before and after each session.
  • Sham Comparator: sham group
    Participants receive a single 20-minute session of sham TIS using identical electrode placement and setup, but without effective 40 Hz stimulation. In this randomized crossover design, each participant also undergoes an active TIS session on a separate visit, with at least 7 days between sessions. Memory, dual-task postural control, and fMRI assessments are conducted before and after each session.

Primary Outcome Measure

Change From Pre-intervention in Object-Scene Associative Memory Retrieval Accuracy After Stimulation [ Time Frame: Immediately before and after each 20-minute stimulation session during each crossover period ]

Central Contacts

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