A Study to Evaluate Effect of AZD6234 as an Adjunct to Incretin-based Therapies in Adult Participants With Obesity or Overweight With Weight-related Comorbidity With or Without Type 2 Diabetes Mellitus

Part of paid clinical trials in Escondido, California.

Sponsor
AstraZeneca
Study ID
NCT07776509
Phase
PHASE3
Status
Recruiting
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Conditions

  • Obesity or Overweight
  • Weight-Related Comorbidity
  • With/Without Diabetes Mellitus, Type 2

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • AZD6234 — DRUG
    IMP injected subcutaneously, once a week.
  • Placebo — DRUG
    Placebo matching IMP dose injected subcutaneously, once a week.

Study Details

The study will evaluate how well AZD6234 works and how safe it is in adults with excess weight or obesity. Efficacy of AZD6234 will be compared to placebo in percent body weight change from baseline at 68 weeks of treatment.

Key Dates

First listed
Aug 20, 2026
Start date
Aug 24, 2026
Status verified
Sep 2026
Primary completion
Aug 9, 2028
Completion
Aug 9, 2028

Study Design

Enrollment
500 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: AZD6234
    AZD6234
  • Placebo Comparator: Placebo
    Matching placebo

Primary Outcome Measure

Percent change in body weight from baseline at 68 weeks of treatment [ Time Frame: 68 weeks ]

Central Contacts

Locations (23)

FacilityCityStateZIPSite coordinators
Research SiteEscondidoCalifornia92025-
Research SiteLincolnCalifornia95648-
Research SiteWalnut CreekCalifornia94598-
Research SiteFleming IslandFlorida32003-
Research SiteJacksonvilleFlorida32205-
Research SiteStockbridgeGeorgia30281-
Research SiteWoodstockGeorgia30189-
Research SiteChampaignIllinois61822-
Research SiteChicagoIllinois60640-
Research SiteBeltsvilleMaryland20705-
Research SiteOxon HillMaryland20745-
Research SiteKansas CityMissouri64111-
Research SiteLas VegasNevada89101-
Research SiteSomersetNew Jersey08873-
Research SiteStatesvilleNorth Carolina28625-
Research SiteFargoNorth Dakota58104-
Research SiteColumbusOhio43215-
Research SitePortlandOregon97202-
Research SiteSmithfieldPennsylvania15478-
Research SiteFranklinTennessee37067-
Research SiteHoustonTexas77043-
Research SiteManassasVirginia20110-
Research SiteRentonWashington98057-

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