Establishment of a Biological Collection to Develop Translational Preclinical Models for the Study of Tumors and Diseases of the Gastrointestinal Tract

Sponsor
University Hospital, Strasbourg, France
Study ID
NCT07782203
Status
Recruiting
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Conditions

  • Gastrointestinal Cancer
  • IBD

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • biopsy — PROCEDURE
    collect tissues and blood cell

Study Details

The causes underlying the development of chronic inflammatory bowel diseases (IBD) and digestive cancers remain poorly understood. They involve both genetic susceptibilities and multiple environmental factors. Research and the development of new therapeutic strategies are essential to provide patients with novel treatment opportunities. A deep understanding of the tumor ecosystem at the molecular level, as well as the interactions between different cell types, is crucial to identify and validate new therapeutic targets. Since animal cancer models have shown their limitations in translating results to humans, studies models are often based on autologous patient tissues and sera. These innovative models make it possible to: * model tumors ex vivo, * perform screenings of new candidate molecules, * or test tumor response to existing therapies in the context of personalized medicine. This work has led to numerous publications on advanced digestive cancers, such as those of the liver or the bile acid pathway To create ex vivo models and reconstruct the tumor in vitro, experiments require treating tumor cells with blood from the same patient (autologous), collected simultaneously with the tumor resection. The tumor tissues used in culture are obtained from residual material of anatomopathological analyses performed as part of clinical care.

Key Dates

First listed
Aug 24, 2026
Start date
Mar 18, 2026
Status verified
Sep 2025
Primary completion
Dec 30, 2026
Completion
Dec 30, 2027

Study Design

Enrollment
400 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER

Arms

  • Other: gastrointestinal surgery indicated
    Patients for whom gastrointestinal surgery is indicated in the context of IBD or suspected gastrointestinal cancer (esophagus, stomach, colon/rectum
  • Other: gastrointestinal endoscopy planned for IBD
    Patients for whom gastrointestinal endoscopy is planned in the context of suspected or follow-up of IBD
  • Other: gastrointestinal endoscopy planned for cancer
    Patients for whom gastrointestinal endoscopy is planned in the context of suspected gastrointestinal cancer

Primary Outcome Measure

Number of tissue samples suitable for cell culture procedures [ Time Frame: At the time of surgery or digestive endoscopy ]

Central Contacts

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