Pericapsular Nerve Group Block Versus Intrathecal Morphine for Pain After Hip Surgery

Sponsor
Selcuk University
Study ID
NCT07784192
Status
Recruiting
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Conditions

  • Analgesia
  • Hip Arthroplasty
  • Hip Arthroplasty, Total
  • Hip Fractures (ICD-10 72.01-72.2)
  • Postoperative Pain

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Not accepted

Interventions

  • Morpine — DRUG
    Preservative-free morphine hydrochloride 100 micrograms will be added to 10 mg of hyperbaric bupivacaine 0.5% and administered into the intrathecal space at the L3-L4 or L4-L5 interspace as part of spinal anesthesia.
  • Ultrasound-guided pericapsular nerve group block — PROCEDURE
    After spinal anesthesia, an ultrasound-guided pericapsular nerve group block will be performed on the operative side. A 21 gauge, 80 to 100 mm echogenic needle will be advanced in-plane from lateral to medial into the fascial plane between the iliopubic eminence and the iliopsoas tendon, and 20 mL of bupivacaine 0.5% will be injected after negative aspiration.
  • Bupivacaine — DRUG
    Hyperbaric bupivacaine 0.5%, 10 mg, will be administered intrathecally in both groups as the spinal anesthetic. In the PENG block group, an additional 20 mL of bupivacaine 0.5% will be used for the block.

Study Details

Pain after hip replacement surgery is often severe and is commonly treated with opioids, which may cause nausea, vomiting, sedation, difficulty passing urine and slow breathing. This study will compare two ways of controlling pain in adults having hip surgery under spinal anesthesia. One group will receive morphine added to the spinal injection. The other group will receive an ultrasound-guided pericapsular nerve group (PENG) block, in which local anesthetic is injected near the nerves that carry pain signals from the hip joint. Participants will be assigned to one of the two groups by chance. Sixty-four adults aged 18 to 65 years will take part, with 32 in each group. Pain scores at rest and during movement, the total amount of morphine used through a patient-controlled pump, the time until the first request for extra pain medicine, the amount of additional paracetamol used, side effects such as nausea and vomiting, and complications related to the block will be compared between the groups during the first 48 hours after surgery.

Key Dates

First listed
Aug 25, 2026
Start date
Aug 24, 2026
Status verified
Aug 2026
Primary completion
Sep 18, 2026
Completion
Sep 25, 2026

Study Design

Enrollment
64 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE

Arms

  • Active Comparator: Intrathecal Morphine Group
    Patients receive spinal anesthesia with 10 mg hyperbaric bupivacaine 0.5% plus 100 micrograms of preservative-free morphine into the intrathecal space.
  • Experimental: PENG Block Group
    Patients receive spinal anesthesia with 10 mg hyperbaric bupivacaine 0.5% alone, followed by an ultrasound-guided pericapsular nerve group (PENG) block on the operated side with 20 mL of 0.5% bupivacaine.

Primary Outcome Measure

Cumulative intravenous morphine consumption at 24 hours [ Time Frame: 0 to 24 hours after surgery ]

Central Contacts

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