Pre-pubertal Low Dose Transdermal Estradiol in Turner Syndrome

Part of paid clinical trials in Washington D.C., District of Columbia.

Sponsor
Children's National Research Institute
Study ID
NCT07784582
Phase
PHASE2
Status
Not Yet Recruiting

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Conditions

  • Primary Ovarian Insufficiency
  • Turner Syndrome

Eligibility Criteria

Sex
FEMALE
Age
8 Years - 12 Years
Healthy Volunteers
Not accepted

Interventions

  • Estradiol transdermal patch 0.025mg/24 hours- 1/8th fractionated patch — DRUG
    Estradiol transdermal patch 0.025mg/24 hours- 1/8th fractionated patch will be applied and changed weekly for 6 months

Study Details

This is a research study to find out if treatment with transdermal estradiol patches started between 8 to 11.5 years is safe in girls with Turner syndrome who have ovarian failure and to see whether it may improve performance on two tests of working speed and short-term memory.

Key Dates

First listed
Aug 25, 2026
Start date
Sep 1, 2026
Status verified
Aug 2026
Primary completion
Jun 30, 2027
Completion
Jun 30, 2027

Study Design

Enrollment
15 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Estradiol Treatment
    Patients opt to receive 6 months of transdermal ultra low dose estradiol treatment

Primary Outcome Measure

Pattern Comparison processing speed test [ Time Frame: 6 months ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Children's National HospitalWashington D.C.District of Columbia20010
Kimberly Pitner, MSHS, BSN, RN
[email protected]
202-476-1403
Roopa Kanakatti Shankar, MBBS, MS (PRINCIPAL_INVESTIGATOR)

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By research site
Children's National Hospital· Washington D.C., DC

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