A Study to Evaluate Effect of AZD6234 in Adult Participants With Obesity or Overweight With Weight-related Comorbidity Without Type 2 Diabetes Mellitus

Part of paid clinical trials in Dothan, Alabama.

Sponsor
AstraZeneca
Study ID
NCT07784725
Phase
PHASE3
Status
Recruiting
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Conditions

  • Obesity or Overweight

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • AZD6234 — DRUG
    IMP injected subcutaneously, once a week. Unit dose strength as per CSP.
  • Placebo — DRUG
    Placebo matching IMP dose injected subcutaneously, once a week.

Study Details

The study will evaluate how well AZD6234 works and how safe it is in adults with excess weight or obesity. Efficacy of AZD6234 will be compared to placebo in percent body weight change from baseline at 68 weeks of treatment

Key Dates

First listed
Aug 25, 2026
Start date
Aug 19, 2026
Status verified
Aug 2026
Primary completion
Aug 11, 2028
Completion
May 21, 2029

Study Design

Enrollment
2,500 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: AZD6234 Dose 1
    AZD6234 Dose 1
  • Experimental: AZD6234 Dose 2
    AZD6234 Dose 2
  • Placebo Comparator: Placebo
    Matching placebo

Primary Outcome Measure

Percent change in body weight from baseline at 68 weeks of treatment [ Time Frame: 68 weeks ]

Central Contacts

Locations (33)

FacilityCityStateZIPSite coordinators
Research SiteDothanAlabama36305-
Research SiteHuntsvilleAlabama35801-
Research SiteMesaArizona85206-
Research SiteEscondidoCalifornia92025-
Research SiteClearwaterFlorida33765-
Research SiteJacksonvilleFlorida32205-
Research SiteStockbridgeGeorgia30281-
Research SiteChampaignIllinois61822-
Research SiteChicagoIllinois60640-
Research SiteAmesIowa50010-
Research SiteTroyMichigan48098-
Research SiteJefferson CityMissouri65109-
Research SiteKansas CityMissouri64131-
Research SiteButteMontana59701-
Research SiteLas VegasNevada89101-
Research SiteJersey CityNew Jersey07306-
Research SiteCortlandNew York13045-
Research SiteStatesvilleNorth Carolina28625-
Research SiteFargoNorth Dakota58104-
Research SiteColumbusOhio43215-
Research SiteTulsaOklahoma74133-
Research SitePortlandOregon97202-
Research SitePhiladelphiaPennsylvania19107-
Research SiteSmithfieldPennsylvania15478-
Research SiteKingsportTennessee37660-
Research SiteHoustonTexas77043-
Research SiteSan AntonioTexas78231-
Research SiteSugar LandTexas77478-
Research SiteWacoTexas76710-
Research SiteSalt Lake CityUtah84124-
Research SiteArlingtonVirginia22206-
Research SiteRentonWashington98057-
Research SiteSeattleWashington98104-

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