Arm Elevation for Prevention of Propofol Injection Pain

Conditions

• Propofol Injection Pain

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Passive arm elevation — PROCEDURE
  The cannulated arm is passively elevated approximately 60 to 90 degrees at the start of propofol injection and maintained briefly during and immediately after the injection before being returned to heart level.
• Normal saline — DRUG
  Normal saline 0.9%, 2 mL, administered intravenously as sham lidocaine before propofol injection.
• Lidocaine — DRUG
  Lidocaine 2%, 2 mL, administered intravenously before propofol injection.
• Propofol — DRUG
  Standard LCT propofol administered as a standardized subanesthetic test dose, calculated as one-quarter of a 2.5 mg/kg induction dose using total body weight up to BMI 30 or ideal body weight above BMI 30, with a maximum study dose of 50 mg.
• Sham arm elevation — PROCEDURE
  The contralateral non-IV arm is elevated while the cannulated arm remains neutral.

Study Details

The purpose of this research is to determine whether a simple technique, temporarily raising the arm during the injection of propofol (a commonly used medication for anesthesia), can reduce the pain that some people experience when the medication is given through an IV. The study will compare this technique with the current standard approach of using lidocaine (a numbing medication), as well as a combination of both methods, to determine which approach is most effective at reducing injection pain.

Key Dates

First listed

Aug 25, 2026

Start date

Sep 30, 2026

Status verified

Aug 2026

Primary completion

Jan 31, 2027

Completion

Feb 28, 2027

Study Design

Enrollment

45 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Arms

• Experimental: Arm Elevation Only
  Participants receive saline pretreatment followed by propofol injection with passive elevation of the cannulated arm during propofol injection.
• Active Comparator: Lidocaine Only
  Participants receive lidocaine pretreatment followed by propofol injection while the cannulated arm remains neutral. The non-IV arm is elevated as a sham maneuver.
• Experimental: Lidocaine Plus Arm Elevation
  Participants receive lidocaine pretreatment followed by propofol injection with passive elevation of the cannulated arm during propofol injection.

Primary Outcome Measure

Incidence of Any Propofol Injection Pain [ Time Frame: Within approximately 30 seconds from the start of propofol injection. ]

Central Contacts

• Mariel Anne Reyes
  904-953-4797
  [email protected]
• Ally Sapin
  904-953-7929
  [email protected]

Locations (1)

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