Metatranscriptomic Markers of Colonic Neoplasia

Conditions

• Colorectal Polyps

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Accepted

Interventions

• This is an observational study that has no interventions — OTHER
  This is an observational study that has no interventions

Study Details

This study is a collaboration between Viome Life Sciences and Scripps Research Institute to develop and validate a noninvasive molecular diagnostic test for the detection of colorectal polyps. Approximately 1,000 participants undergoing colonoscopy will provide saliva and stool samples prior to their procedure. Molecular features identified in these samples will be evaluated in relation to colonoscopy findings to develop a predictive model for colorectal polyp detection. The resulting model will then be evaluated in an independent validation dataset to assess its performance for identifying individuals with colorectal polyps.

Key Dates

First listed

Aug 26, 2026

Start date

Dec 20, 2025

Status verified

Aug 2026

Primary completion

Jan 30, 2027

Completion

Jan 30, 2027

Study Design

Enrollment

1,000 participants (estimated)

Primary Outcome Measure

Diagnostic performance [ Time Frame: Participants collect study samples between 4 weeks and 1 day prior to initiation of bowel preparation for colonoscopy. Colonoscopy findings and associated pathology results are subsequently collected electronically as part of the study. ]

Central Contacts

• Momchilo Vuyisich, PhD
  855-958-4663
  [email protected]

Locations (1)

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