Assessing the Short-Term Effects of Multi-Fiber Supplementation on Gut Health

Conditions

• Mixed Fiber Supplementation for Healthy Adults

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Accepted

Interventions

• Prebiotic — DIETARY_SUPPLEMENT
  Formulated prebiotic supplement designed to be accessible to gut microbiota members and assist with bowel movement regularity
• Placebo — DIETARY_SUPPLEMENT
  Placebo supplementation intervention, with only flavoring agents and no prebiotic fiber

Study Details

This is a randomized, parallel-group interventional study evaluating the short-term gastrointestinal effects of a standardized multi-fiber supplement in healthy adults. Approximately 100 participants (50 per arm) aged 18 and older will be randomized to receive either the multi-fiber supplement or a control (flavoring agent only) daily for 10 days. Objectives include assessing effects on stool characteristics, specifically frequency and consistency, as well as changes in metagenomically inferred short-chain fatty acid production potential from the microbiota. Eligible participants must be free of chronic disease, acute illness, and recent antibiotic, probiotic, or prebiotic use. Total participation duration is 10 days.

Key Dates

First listed

Aug 26, 2026

Start date

Aug 31, 2026

Status verified

Jul 2026

Primary completion

Aug 31, 2028

Completion

Aug 31, 2029

Study Design

Enrollment

100 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Arms

• Experimental: Mixed Fiber Supplementation Intervention Arm
• Placebo Comparator: Placebo Supplementation Arm

Primary Outcome Measure

Change in metagenomically inferred SCFA production potential [ Time Frame: Change observed from baseline sample (Day 0) to second sample (Day 10) ]

Locations (1)

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