Sensory and Physical Reactions to Beverage Cues

Part of paid clinical trials in Dallas, Texas.

Sponsor
University of Texas Southwestern Medical Center
Study ID
NCT07788716
Status
Recruiting
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Conditions

  • Alcohol Use Disorder (AUD)

Eligibility Criteria

Sex
ALL
Age
21 Years - 70 Years
Healthy Volunteers
Not accepted

Interventions

  • Alcohol Cue Reactivity Paradigm — BEHAVIORAL
    Standardized 3-minute visual, olfactory, and tactile exposure to beverage cues (water, and two similar appearing beverages) accompanied by guided audio instructions.

Study Details

The goal of this clinical trial is to evaluate changes in craving and sensory responses to different beverage cues in adults (aged 21-70) with current mild or greater alcohol use disorder (AUD). The main questions it aims to answer are: * Does exposure to different beverage cues elicit distinct changes in subjective craving? * How do beverage liking, peak craving, and the return of craving to baseline compare across different test-beverage conditions? Researchers will compare Session A (Test Beverage Condition A) to Session B (Test Beverage Condition B) in a randomized crossover design to see if sensory and expectancy effects influence craving responses without consumption. Participants will: * Complete two separate 3-minute cue reactivity trials per session (a baseline water cue, followed by a test-beverage cue) while listening to guided audio instructions and holding/smelling the beverage without drinking it. * Rate their craving and beverage liking using visual analog scales (VAS) immediately after each trial. * Provide breathalyzer readings (BrAC), vital signs, and safety/medication checks at both study visits. * Complete diagnostic and drinking history assessments (such as the SCID-5, TLFB, and ACQ-SF-R).

Key Dates

First listed
Aug 26, 2026
Start date
Oct 31, 2026
Status verified
Aug 2026
Primary completion
Oct 31, 2027
Completion
Dec 31, 2027

Study Design

Enrollment
20 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER

Arms

  • Experimental: Beverage A
    Exposure to a visually matched beverage to Beverage B
  • Experimental: Beverage B
    Exposure to a visually matched beverage to Beverage A

Primary Outcome Measure

Change in Subjective Alcohol Craving Score, Visual Analog Scale (VAS) [ Time Frame: Visit 1 (baseline) through Visit 2, an average of 1 week. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Univeristy of Texas Southwestern Medical CenterDallasTexas75390
E. Sherwood Brown, MD, PhD
[email protected]
214-645-6950

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Univeristy of Texas Southwestern Medical Center· Dallas, TX

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