Photon-counting CT Scan vs Standard HRCT Scan in the Identification of Idiopathic Pulmonary Fibrosis

Sponsor
Istituto Clinico Humanitas
Study ID
NCT07790614
Status
Recruiting
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Conditions

  • CT
  • CT Photon-Counting
  • CT Scan
  • ILD
  • IPF
  • Idiopathic Pulmonary Fibrosis
  • Idiopathic Pulmonary Fibrosis (IPF)
  • Interstitial Lung Disease (ILD)
  • Interstitial Lung Disease Due to Systemic Disease (Telomere Biology Disorder)
  • Interstitial Lung Diseases

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Photon counting CT — DIAGNOSTIC_TEST
    Non-contrast enhanced CT will be acquired in spectral ultra-high-resolution mode on a clinical dual-source photon-counting detector CT (PCDCT) (NAEOTOM Alpha, Siemens Healthineers AG, Forchheim, Germany). All scans will be acquired with automated exposure control.

Study Details

The CT-IPF ANTHEM study is designed to prospectively compare PCDCT to HRCT scan in the identification of specific ILD diagnosis discussed during the multidisciplinary discussion to increase diagnostic confidence and reduce unclassifiable ILD cases.

Key Dates

First listed
Aug 27, 2026
Start date
Mar 25, 2025
Status verified
Apr 2026
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
156 participants (estimated)

Arms

  • Arm: ILD patients undergoing radiological evaluation
    Eligible partecipants will be adults (≥ 18 years of age) with a new diagnosis of ILD referred to the outpatient clinic of ILD of Humanitas Research Hospital, Rozzano - Milano) and with the need of a MDD discussion to reach a diagnosis.

Primary Outcome Measure

Reduction of unclassifiable ILD diagnosis after MDD comparing PCDCT vs standard Chest HRCT scan using McNemar test [ Time Frame: 2 years ]

Central Contacts

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