Circulating Tumor DNA (ctDNA) in High Grade Upper Tract Urothelial Cancer (UTUC)

Part of paid clinical trials in Baltimore, Maryland.

Sponsor
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Study ID
NCT07793240
Status
Not Yet Recruiting

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Conditions

  • Upper Tract Urothelial Carcinoma

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Signatera testing — DIAGNOSTIC_TEST
    Standard Signatera testing for ctDNA at or close to baseline, every 4-6 weeks on treatment, before and after surgical intervention, on surveillance and or adjuvant therapy.

Study Details

The study will evaluate the feasibility of collecting ctDNA data for UTUC patients in perioperative setting and if the data generated can help with design of future prostpective trials for perioperative therapy in UTUC.

Key Dates

First listed
Aug 28, 2026
Start date
Oct 1, 2026
Status verified
Aug 2026
Primary completion
Oct 1, 2028
Completion
Oct 1, 2029

Study Design

Enrollment
20 participants (estimated)

Arms

  • Arm: High Grade (HG) Upper Tract Urothelial Cancer (UTUC)
    Patients HG UTUC planned for systemic therapy and or surgical intervention will be recruited and have sequential ctDNA ordered as per standard Signatera testing (approved for patients with high risk urothelial cancer undergoing immunotherapy or in perioperative setting) at or close to baseline, every 4-6 weeks on treatment, before and after surgical intervention, on surveillance and or adjuvant therapy.

Primary Outcome Measure

Percent of of tumor informed ctDNA test results on Signatera platform available [ Time Frame: until end of surveillance or adjuvant therapy, approximately 5 years ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Johns Hopkins University: Sidney Kimmel Comprehensive Cancer CenterBaltimoreMaryland21287
Sin Chan, MS
[email protected]
410-614-3630
Jeannie Hoffman-Censtis, MD (PRINCIPAL_INVESTIGATOR)

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By research site
Johns Hopkins University: Sidney Kimmel Comprehensive Cancer Center· Baltimore, MD

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