Sleep to Predict Recovery In Unconscious Patients With Acute Brain Injury

Part of paid clinical trials in Miami, Florida.

Sponsor
Columbia University
Study ID
NCT07794605
Status
Not Yet Recruiting

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Conditions

  • Intracerebral Hemorrhage (ICH)
  • Traumatic Brain Injury (TBI) Patients

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Study Details

Severe brain injuries can leave people in states where they are unconscious or only partly aware, such as a coma. These conditions are common after injuries like head trauma or bleeding in the brain. One of the biggest challenges for doctors is knowing if - or when - a patient will wake up and regain awareness. This research study is being done to determine if patterns in brain activity during sleep (measured by EEG) can help doctors better predict how quickly someone will wake up and recover after a serious brain injury, as well as how well they might do in the long term. It also aims to develop new ways of using EEG to track how the brain's networks heal and reconnect over time.

Key Dates

First listed
Aug 31, 2026
Start date
Sep 1, 2026
Status verified
Aug 2026
Primary completion
Sep 1, 2030
Completion
Sep 1, 2031

Study Design

Enrollment
230 participants (estimated)

Arms

  • Arm: Intracerebral Hemorrhage and Traumatic Brain Injury
    Adult patients with acute neurological injury with Disorders of Consciousness (traumatic brain injury, and intracerebral hemorrhage).

Primary Outcome Measure

P-value for prediction of the detection of cognitive motor dissociation (CMD) [ Time Frame: Day 9 ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
University of Miami and Jackson Health System (UM/JHS)MiamiFlorida33136
Ayham Alkhachroum, MD
[email protected]
305-243-6175
Ayham Alkhachroum, MD (PRINCIPAL_INVESTIGATOR)
Columbia University Medical CenterNew YorkNew York10032
Jan Claassen, MD
[email protected]
212-305-7236
Jan Claassen, MD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Miami, FL

By research site
University of Miami and Jackson Health System (UM/JHS)· Miami, FLColumbia University Medical Center· New York, NY

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